TLR7

Gene Symbol TLR7
Entrez Gene 51284
Alt Symbol TLR7-like
Species Human
Gene Type protein-coding
Description toll-like receptor 7
Other Description toll-like receptor 7-like
Swissprots D1CS69 Q9NR98 Q9NYK1
Accessions AAZ99021 AAZ99022 AAZ99023 AAZ99024 AAZ99025 AAZ99026 EAW98807 Q9NYK1 AB445659 BAG55056 AF240467 AAF60188 AF245702 AAF78035 AK313858 BAG36586 AY358292 AAQ88659 BC033651 AAH33651 DQ891269 ABM82195 DQ894457 ABM85383 NM_016562 NP_057646
Function Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). {ECO:0000250}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Endosome {ECO:0000250}. Lysosome {ECO:0000250}. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. {ECO:0000250}.
Tissue Specificity Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.
Top Pathways Toll-like receptor signaling pathway, Measles, Influenza A

TLR7 293 Cell Lysate - 406670 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

TLR7 Overexpression Lysate (Native) - NBL1-16956 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: TLR7 Overexpression Lysate (Adult Normal) [NBL1-16956] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TLR7.

Human TLR7 NF-kB/SEAP - (SEAPorter™) Stable Reporter Cell Line - NBP2-26278 from Novus Biologicals

Category Cell Line
Prices $1,129.00
Sizes 1 vial
Species Human
Flow Cytometry: Human TLR7 NF-kB/SEAP - (SEAPorter™) Stable Reporter Cell Line [NBP2-26278] - Intracellular staining of TLR7 in the TLR7 reporter cell line was analyzed by flow cytometry using PE-conjugated anti-TLR7 antibody. Flow samples were prepared using the Intracellular TLR Staining Flow Kit. Purple: Cells without antibody; Green: NF-kB/SEAPorterTM HEK 293 cell line stained with 2 ug anti-TLR7-PE. Red: TLR7 reporter cell line stained with anti-TLR7-PE.

Human TLR7 Stable Cell Line - NBP2-26270 from Novus Biologicals

Category Cell Line
Prices $849.00
Sizes 1 vial
Species Human
Western Blot: Human TLR7 Stable Cell Line [NBP2-26270] - analysis of TLR7 expression in the TLR7 stable cell line using an HA antibody (20 ug total protein/lane). Legend. Vect: Vector control stable cell line; TLR7: TLR7 stable cell line.

TLR7 Over-expression Lysate Product - GWB-100C5E from Genway Biotech

Category Cell Lysate
Prices $445.00
Sizes 100 µg
Species Human

Panoply™ Human TLR7 Knockdown Stable Cell Line - CSC-DC016006 from Creative biogene

Category Cell Line
Species Human
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