| Gene Symbol |
CSN5A
|
| Entrez Gene |
838899
|
| Alt Symbol |
AJH1, ARABIDOPSIS JAB1 HOMOLOG 1, COP9 signalosome 5A, CSN5, F19G10.12, F19G10_12, JAB1, PUTATIVE JUN KINASE ACTIVATOR
|
| Species |
Arabidopsis thaliana
|
| Gene Type |
protein-coding
|
| Description |
COP9 signalosome complex subunit 5a
|
| Other Description |
-
|
| Swissprots |
Q84WE7 O23130 O82524 Q8LAZ7
|
| Accessions |
AAB72159 AEE30309 AEE30310 CAY36796 CAY36806 CCF77104 Q8LAZ7 AF042334 AAB96974 AF395062 AAL58105 BT029486 ABL66743 NM_102139 NP_173705 NM_202161 NP_973890
|
| Function |
Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex (By similarity). The CSN complex is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of PSIAA6 by regulating the activity of the Ubl ligase SCF-TIR complex. {ECO:0000250, ECO:0000269|PubMed:11337587, ECO:0000269|PubMed:9811788}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:9811788}. Nucleus {ECO:0000269|PubMed:9811788}.
|
| Tissue Specificity |
Ubiquitously expressed. Highly expressed in flowers and roots. Expressed at lower level in seedlings and siliques. {ECO:0000269|PubMed:9811788}.
|