HDAC1

Gene Symbol	HDAC1
Entrez Gene	3065
Alt Symbol	GON-10, HD1, RPD3, RPD3L1
Species	Human
Gene Type	protein-coding
Description	histone deacetylase 1
Other Description	reduced potassium dependency, yeast homolog-like 1
Swissprots	Q92534 Q13547
Accessions	BAG70921 EAX07540 EAX07541 Q13547 AB451297 BAG70111 AB451430 BAG70244 AK225555 AK296308 BAH12310 AK299241 BAG61272 AK299792 BAG61671 AK313061 AY627042 AAT44863 BC000301 AAH00301 BX648055 CAI46269 CR541717 CAG46518 D50405 BAA08909 DQ891398 ABM82324 DQ894577 ABM85503 U50079 AAC50475 XM_011541309 XP_011539611 NM_004964 NP_004955
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A
Subcellular Location	Nucleus.
Tissue Specificity	Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.
Top Pathways	Notch signaling pathway, MicroRNAs in cancer, Alcoholism, Epstein-Barr virus infection, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human HDAC1 full length protein - ab101661 from Abcam Category Protein Source Baculovirus Species Human

Active human HDAC1 full length protein - ab104121 from Abcam Category Protein Source Baculovirus Species Human

HDAC1 peptide - ab174565 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human HDAC1 peptide - ab20434 from Abcam Category Peptide

Zebrafish HDAC1 peptide - ab41405 from Abcam Category Peptide

Zebrafish HDAC1 peptide - ab41406 from Abcam Category Peptide

HDAC1 Antibody Blocking Peptide - LS-E675 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HDAC1 Antibody Blocking Peptide - LS-E2334 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HDAC1 Antibody Blocking Peptide - LS-E27858 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HDAC1 Antibody Blocking Peptide - LS-E11321 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HDAC1 Antibody Blocking Peptide - LS-E11142 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HDAC1 Antibody Blocking Peptide - LS-E13857 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HDAC1 Antibody Blocking Peptide - LS-E13858 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HDAC1 Antibody Blocking Peptide - LS-E26066 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HDAC1 Recombinant Protein - H00003065-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human HDAC1 Protein - H00003065-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

HDAC1 Peptide - P0209 from Novus Biologicals Category Peptide Species Human

HDAC1 Peptide - P0207 from Novus Biologicals Category Peptide Species Human

HDAC1-Antibody-S421-Blocking-Peptide - BP1101d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HDAC1-Antibody-C-term-Blocking-Peptide - BP1101a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HDAC1-Antibody-N-term-Blocking-peptide - BP13296a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HDAC1-Antibody-Center-S423-Blocking-Peptide - BP16867c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HDAC1 Enzyme - orb198358 from Biorbyt Category Protein Prices $553.00 Sizes 20 μg Species Human

Human HDAC1 protein - orb244264 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

HDAC 1 Blocking Peptide - 33R-10516 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

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