Blm

Gene Symbol Blm
Entrez Gene 12144
Alt Symbol -
Species Mouse
Gene Type protein-coding
Description Bloom syndrome, RecQ helicase-like
Other Description Bloom syndrome homolog|Bloom syndrome protein homolog|mBLM|recQ helicase homolog
Swissprots O88198 O88700
Accessions EDL06982 EDL06983 O88700 AB008674 BAA32001 AK137022 AK139975 AK157898 AK164605 BB614580 BB655193 BC157095 AAI57096 Z98263 CAB10933 NM_001042527 NP_001035992 NM_007550 NP_031576
Function Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE). {ECO:0000269|PubMed:9840919}.
Subcellular Location Nucleus {ECO:0000250}. Note=Together with SPIDR, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea (HU) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a RMI complex- and SPIDR- dependent manner (By similarity). {ECO:0000250}.
Tissue Specificity Highly expressed in testis 12-14 days after birth (corresponding to the pachytene phase) and at much lower levels in brain, heart, liver, lung, thymus, kidney and spleen. {ECO:0000269|PubMed:9655940}.
Top Pathways Homologous recombination, Fanconi anemia pathway

Bloom syndrome protein (BLM), Mouse, ELISA Kit - E03B0804 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Mouse BLM ELISA Kit - E045908 from Biobool

Category ELISA Kit
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