MAP3K7

Gene Symbol	MAP3K7
Entrez Gene	6885
Alt Symbol	MEKK7, TAK1, TGF1a
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase kinase kinase 7
Other Description	TGF-beta activated kinase 1|TGF-beta-activated kinase 1|transforming growth factor-beta-activated kinase 1
Swissprots	B2RE27 O43317 Q5TDT7 Q5TDN2 Q9NZ70 O43318 O43319 E1P523 Q5TDN3 Q9NTR3
Accessions	ABC40734 EAW48525 EAW48526 EAW48527 EAW48528 EAW48529 O43318 AB009356 BAA25025 AB009357 BAA25026 AB009358 BAA25027 AF218074 AAF27652 AI147171 AK055901 AK299268 BAG61290 AK315774 BAG38124 AL050393 CAB43687 AL520975 BC017715 AAH17715 BM172351 BT019654 AAV38460 BT019655 AAV38461 BX648277 XM_006715553 XP_006715616 NM_003188 NP_003179 NM_145331 NP_663304 NM_145332 NP_663305 NM_145333 NP_663306
Function	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12242293}. Cell membrane {ECO:0000269|PubMed:12242293}; Peripheral membrane protein {ECO:0000269|PubMed:12242293}; Cytoplasmic side {ECO:0000269|PubMed:12242293}. Note=Although the majority of MAP3K7/TAK1 is found in the cytosol, when complexed with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2, it is also localized at the cell membrane.
Tissue Specificity	Isoform 1A is the most abundant in ovary, skeletal muscle, spleen and blood mononuclear cells. Isoform 1B is highly expressed in brain, kidney and small intestine. Isoform 1C is the major form in prostate. Isoform 1D is the less abundant form. {ECO:0000269|PubMed:11118615}.
Top Pathways	AMPK signaling pathway, Epstein-Barr virus infection, Herpes simplex infection, TNF signaling pathway, Wnt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® TAK1 siRNA I - 6317 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® TAK1 siRNA II - 6318 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

Tak1 CRISPR/Cas9 KO Plasmid (h) - sc-400364 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Tak1 HDR Plasmid (h) - sc-400364-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Tak1 Double Nickase Plasmid (h) - sc-400364-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Tak1 Double Nickase Plasmid (h2) - sc-400364-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Tak1 CRISPR Activation Plasmid (h) - sc-400364-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Tak1 CRISPR Activation Plasmid (h2) - sc-400364-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Tak1 Lentiviral Activation Particles (h) - sc-400364-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Tak1 Lentiviral Activation Particles (h2) - sc-400364-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Tak1 siRNA (h) - sc-36606 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Tak1 shRNA Plasmid (h) - sc-36606-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Tak1 shRNA (h) Lentiviral Particles - sc-36606-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TAK1 RNAi - H00006885-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

TAK1 RNAi - H00006885-R02V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

TAK1 RNAi - H00006885-R10 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

TAK1 RNAi - H00006885-R12 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU081791 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1157 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1158 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1156 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1545 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1544 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1543 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1545 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

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