| Gene Symbol | HSPA1B |
|---|---|
| Entrez Gene | 3304 |
| Alt Symbol | HSP70-1B, HSP70-2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | heat shock 70kDa protein 1B |
| Other Description | HSP70-1/HSP70-2|HSP70.1/HSP70.2|heat shock 70 kDa protein 1/2|heat shock 70 kDa protein 1A/1B|heat shock 70kD protein 1B |
| Swissprots | P19790 Q9UQL9 Q5SP17 Q9UQM0 Q5JQI4 P08107 B4E3B6 |
| Accessions | AAA59845 AAA63227 AAD21815 BAB63299 EAX03529 AK295398 BAG58351 AK303967 BAG64891 AL360193 BC001876 BC057397 AAH57397 BC063507 AAH63507 DB015158 DQ896426 ABM87425 NM_005346 NP_005337 |
| Function | In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). {ECO:0000269|PubMed:16537599, ECO:0000269|PubMed:23973223}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. |
| Tissue Specificity | HSPA1B is testis-specific. |
| Top Pathways | Estrogen signaling pathway, Epstein-Barr virus infection, Legionellosis, Influenza A, Measles |