HSPA1B

Gene Symbol HSPA1B
Entrez Gene 3304
Alt Symbol HSP70-1B, HSP70-2
Species Human
Gene Type protein-coding
Description heat shock 70kDa protein 1B
Other Description HSP70-1/HSP70-2|HSP70.1/HSP70.2|heat shock 70 kDa protein 1/2|heat shock 70 kDa protein 1A/1B|heat shock 70kD protein 1B
Swissprots P19790 Q9UQL9 Q5SP17 Q9UQM0 Q5JQI4 P08107 B4E3B6
Accessions AAA59845 AAA63227 AAD21815 BAB63299 EAX03529 AK295398 BAG58351 AK303967 BAG64891 AL360193 BC001876 BC057397 AAH57397 BC063507 AAH63507 DB015158 DQ896426 ABM87425 NM_005346 NP_005337
Function In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). {ECO:0000269|PubMed:16537599, ECO:0000269|PubMed:23973223}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Tissue Specificity HSPA1B is testis-specific.
Top Pathways Estrogen signaling pathway, Epstein-Barr virus infection, Legionellosis, Influenza A, Measles

HSP 70-2 CRISPR/Cas9 KO Plasmid (h) - sc-417733 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSP 70-2 HDR Plasmid (h) - sc-417733-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSP 70-2 Double Nickase Plasmid (h) - sc-417733-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSP 70-2 Double Nickase Plasmid (h2) - sc-417733-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSP 70 CRISPR Activation Plasmid (h) - sc-417733-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSP 70-2 CRISPR Activation Plasmid (h2) - sc-417733-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSP 70-2 Lentiviral Activation Particles (h) - sc-417733-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSP 70-2 Lentiviral Activation Particles (h2) - sc-417733-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSP 70-2 siRNA (h) - sc-105545 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HSP 70-2 shRNA Plasmid (h) - sc-105545-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HSP 70-2 shRNA (h) Lentiviral Particles - sc-105545-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HspA1B RNAi - H00003304-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU129201 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU117971 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10360 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10360 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

HSPA1B siRNA (Human) - CRH2259 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HSPA1A - MBS8204567 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HSPA1B - MBS8220054 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human HSPA1B (NM_005346.4) - SHH315557 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human HSPA1B(NM_005346.4) - SHH133991 from Creative biogene

Category siRNA
Species Reactivities Human

HSPA1B shRNA Plasmid (Human) - CHH2259 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

HSPA1B miRNA 3'UTR clone - MiUTR1H-04732 from Creative biogene

Species Reactivities Human
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