POLR3A

Gene Symbol	POLR3A
Entrez Gene	11128
Alt Symbol	ADDH, HLD7, RPC1, RPC155, hRPC155
Species	Human
Gene Type	protein-coding
Description	polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
Other Description	DNA-directed RNA polymerase III largest subunit|DNA-directed RNA polymerase III subunit A|DNA-directed RNA polymerase III subunit RPC1|RNA polymerase III 155 kDa subunit|RNA polymerase III subunit C1|RNA polymerase III subunit C160|RNA polymerase III subunit RPC155-D
Swissprots	Q8TCW5 Q8IW34 O14802
Accessions	EAW54617 O14802 AF021351 AAB86536 AK024744 AK026023 AK300329 BAH13260 AY091459 AAM12029 AY091460 AAM12030 AY091461 AAM12031 AY091462 AAM12032 BC014399 AAH14399 BC041089 AAH41089 CA449326 DA103416 DA353439 NM_007055 NP_008986
Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsR
Subcellular Location	Nucleus.
Tissue Specificity	Expressed in the brain, in the cortex and the white matter (at protein level). {ECO:0000269|PubMed:21855841}.
Top Pathways	Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

POLR3A (D5Y2D) Rabbit mAb - 12825 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D5Y2D

POLR3A (H-130) - sc-292119 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

POLR3A (K-12) - sc-107058 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

POLR3A (N-16) - sc-107059 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-POLR3A antibody - ChIP Grade - ab96328 from Abcam Prices $387.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-POLR3A antibody - N-terminal - ab138023 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-POLR3A Antibody (C-Terminus) - LS-C111186 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-POLR3A Antibody (aa31-80) - LS-C119917 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-POLR3A Antibody (aa19-68) - LS-C200611 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-POLR3A Antibody (aa182-482) - LS-C185773 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-POLR3A Antibody (Pro68) - LS-C177450 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

POLR3A Antibody - NBP1-53051 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

POLR3A Antibody - NBP1-30516 from Novus Biologicals Prices $349.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

POLR3A Antibody - NBP2-32648 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

POLR3A Antibody - NBP1-83204 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-POLR3A antibody produced in rabbit - HPA037926 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-POLR3A antibody produced in rabbit - SAB2101842 from Sigma-Aldrich Prices $347.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-POLR3A antibody produced in rabbit - HPA037927 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-POLR3A antibody produced in rabbit - SAB2702008 from Sigma-Aldrich Prices $326.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

POLR3A antibody - middle region (ARP48725_P050) - ARP48725_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

POLR3A Antibody (OAAF03587) - OAAF03587 from Aviva Systems Biology Prices $289.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

RPC1 Antibody (OAAF07057) - OAAF07057 from Aviva Systems Biology Prices $289.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

POLR3A antibody - 70R-19412 from Fitzgerald Prices $375.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

POLR3A antibody (OAGA00468) - OAGA00468 from Aviva Systems Biology Prices $340.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

POLR3A antibody - orb69861 from Biorbyt Prices $723.00 Sizes 100 μl Host Rabbit Clonality Polyclonal

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