ZNF268
| Gene Symbol | ZNF268 |
|---|---|
| Entrez Gene | 10795 |
| Alt Symbol | HZF3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | zinc finger protein 268 |
| Other Description | zinc finger protein 3|zinc finger protein HZF3 |
| Swissprots | Q96RH4 Q8TDG8 Q14587 Q9BZJ9 |
| Accessions | EAW54786 EAW54787 EAW54788 EAW54789 Q14587 AF141655 AAG39638 AF317549 AAG59817 AF385187 AAK69307 AF432217 AAL99923 AK027712 BAG51369 AW138703 AY583691 BC058548 BC110542 AAI10543 CN255799 DB079580 DQ057356 DQ057357 DQ057358 DQ057359 DQ057360 DQ057361 X78926 CAA55526 NM_001165881 NP_001159353 NM_001165882 NP_001159354 NM_001165883 NP_001159355 NM_001165884 NP_001159356 NM_001165885 NP_001159357 NM_001165886 NP_001159358 NM_001165887 NP_001159359 NM_003415 NP_003406 NM_152943 NP_694422 |
| Function | Isoform 1: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression. |
| Subcellular Location | Isoform 1: Nucleus {ECO:0000269|PubMed:23665872}. |
| Tissue Specificity | Overexpressed in ovarian cancer tissues compared to normal ovarian tissues. Isoform 1 and isoform 2 are expressed in squamous epithelium tissues. Isoform 2 is overexpressed in squamous cervical cancer (at protein level). Expressed in blood cells. Isoform 1 is expressed in pancreas, lung, skeletal muscle, heart, placenta, liver, kidney and brain. Isoform 2 expressed in chronic lymphocytic leukemia (CLL) and several tumor cell lines. Isoform 3 is expressed in several tumor cells. Isoform 5 is expressed in fetal liver and several tumor cells. Isoform 6 is weakly expressed in brain, lung amd small intestin and in several tumor cells. Isoform 7 is expressed in fetal liver and several tumor cells. {ECO:0000269|PubMed:12200376, ECO:0000269|PubMed:16735226, ECO:0000269|PubMed:16865230, ECO:0000269|PubMed:18949428, ECO:0000269|PubMed:23091055, ECO:0000269|PubMed:23946776}. |
ZNF268 Overexpression Lysate (Native) - NBP2-10224 from Novus Biologicals
![Western Blot: ZNF268 Overexpression Lysate (Adult Normal) [NBP2-10224] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ZNF268.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5305_ZNF268%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10224-img0001.jpg)
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Panoply™ Human ZNF268 Knockdown Stable Cell Line - CSC-DC017956 from Creative biogene
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