Gene Symbol | Ap1s1 |
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Entrez Gene | 11769 |
Alt Symbol | AP19 |
Species | Mouse |
Gene Type | protein-coding |
Description | adaptor protein complex AP-1, sigma 1 |
Other Description | AP-1 complex subunit sigma-1A|HA1 19 kDa subunit|adapter-related protein complex 1 sigma-1A subunit|adapter-related protein complex 1 subunit sigma-1A|adaptor protein complex AP-1 sigma-1A subunit|adaptor protein complex AP-1 subunit sigma-1A|adaptor-related protein complex 1 subunit sigma-1A|adaptor-related protein complex AP-1, sigma 1|clathrin assembly protein complex 1 sigma-1A small chain|clathrin coat assembly protein AP19|golgi adaptor HA1/AP1 adaptin sigma-1A subunit|sigma 1a subunit of AP-1 clathrin|sigma-adaptin 1A|sigma1A-adaptin |
Swissprots | P61967 |
Accessions | EDL19288 EDL19289 P61967 AK002225 BAB21947 AK183413 AK192071 AK196123 AK213207 BC052692 AAH52692 M62418 AAA37243 XM_006504347 XP_006504410 XM_006504348 XP_006504411 NM_007457 NP_031483 |
Function | Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. |
Subcellular Location | Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. |
Tissue Specificity | Detected in brain and embryonic stem cells. |
Top Pathways | Lysosome |
AP1S1 CRISPR/Cas9 KO Plasmid (m) - sc-419130 from Santa Cruz Biotechnology
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AP1S1 HDR Plasmid (m) - sc-419130-HDR from Santa Cruz Biotechnology
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AP1S1 Double Nickase Plasmid (m) - sc-419130-NIC from Santa Cruz Biotechnology
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AP1S1 Double Nickase Plasmid (m2) - sc-419130-NIC-2 from Santa Cruz Biotechnology
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AP1S1 CRISPR Activation Plasmid (m) - sc-419130-ACT from Santa Cruz Biotechnology
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AP1S1 CRISPR Activation Plasmid (m2) - sc-419130-ACT-2 from Santa Cruz Biotechnology
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AP1S1 Lentiviral Activation Particles (m) - sc-419130-LAC from Santa Cruz Biotechnology
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AP1S1 Lentiviral Activation Particles (m2) - sc-419130-LAC-2 from Santa Cruz Biotechnology
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AP1S1 siRNA (m) - sc-60183 from Santa Cruz Biotechnology
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AP1S1 shRNA Plasmid (m) - sc-60183-SH from Santa Cruz Biotechnology
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AP1S1 shRNA (m) Lentiviral Particles - sc-60183-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU088661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN26789 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND26789 from Sigma-Aldrich
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AP1S1 siRNA (Mouse) - CRM0188 from Cohesion Biosciences
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AP1S1 - MBS8231013 from MyBioSource
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shRNA set against Mouse AP1S1 (NM_007457.2) - SHH237790 from Creative biogene
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shRNA set against Mouse Ap1s1(NM_007457.2) - SHG063125 from Creative biogene
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Mouse AP1S1 siRNA - orb279664 from Biorbyt
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AP1S1 shRNA Plasmid (Mouse) - CHM0188 from Cohesion Biosciences
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AP1S1 miRNA 3'UTR clone - MiUTR1M-01539 from Creative biogene
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