PPBP

Gene Symbol PPBP
Entrez Gene 5473
Alt Symbol B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1
Species Human
Gene Type protein-coding
Description pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
Other Description C-X-C motif chemokine 7|CXC chemokine ligand 7|beta-thromboglobulin|connective tissue-activating peptide III|leukocyte-derived growth factor|low-affinity platelet factor IV|macrophage-derived growth factor|neutrophil-activating peptide 2|neutrophil-activating peptide-2|platelet basic protein|small inducible cytokine B7|small inducible cytokine subfamily B, member 7|small-inducible cytokine B7|thrombocidin 1|thrombocidin 2|thromboglobulin, beta-1
Swissprots P02775 Q6IBJ8 B2R5F3
Accessions AAB46877 AAK29642 AAY41004 ADB85518 ADB85519 ADB85520 EAX05695 P02775 AK312166 BAG35100 BC028217 AAH28217 BQ447470 BX443846 CB112845 CR456805 CAG33086 DA419455 DQ891020 ABM81946 DQ894200 ABM85126 M54995 AAA62836 NM_002704 NP_002695
Function LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. {ECO:0000269|PubMed:10877842, ECO:0000269|PubMed:7890771, ECO:0000269|PubMed:8950790, ECO:0000269|PubMed:9794434}.
Subcellular Location Secreted.
Top Pathways Cytokine-cytokine receptor interaction, Chemokine signaling pathway

NAP-2 (T-17) - sc-19224 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NAP-2 (T-17): sc-19224. Western blot analysis of NAP-2 expression in human platelet extract.

NAP-2 (5C7) - sc-57377 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
NAP-2 (5C7): sc-57377. Western blot analysis of NAP-2 expression in human platelet extract.

NAP-2 (3H428) - sc-71642 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
NAP-2 (3H428): sc-71642. Western blot analysis of NAP-2 expression in human platelet extract.

NAP-2 (NYRhNAP-2) - sc-73331 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
NAP-2 (NYRhNAP-2): sc-73331. Western blot analysis of NAP-2 expression in human platelet extract.

NAP-2 (500-M33) - sc-57376 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
NAP-2 (500-M33): sc-57376. Western blot analysis of NAP-2 expression in human platelet extract.

PBP (C-24) - sc-73636 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PBP (C-24): sc-73636. Western blot analysis of PBP expression in human platelet extract.

PBP (L-18) - sc-26916 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PBP (L-18): sc-26916. Western blot analysis of PBP expression in human platelet extract.

Anti-NAP2 antibody - ab169946 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-NAP2 antibody (ab169946) at 1/1000 dilution + Human fetal liver lysate

Anti-NAP2 antibody - ab110617 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-NAP2 antibody - ab58142 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab58142 NAP2 antibody at 1ug/ml.

Anti-NAP2 antibody - ab88084 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-NAP2 antibody (ab88084) at 5 µg/ml + human spleen tissue lysate at 25 µgSecondaryGoat anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-NAP2 antibody - ab103625 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-NAP2 antibody (ab103625) at 1 µg/ml + Human spleen tissue lysate at 50 µg

Anti-NAP2 antibody - ab17596 from Abcam

Prices $370.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-NAP2 antibody [500-M33] - ab9555 from Abcam

Prices $370.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone 500-M33

Anti-NAP2 antibody [5C7] - ab40936 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5C7

Anti-NAP2 antibody (Biotin) - ab83121 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-NAP2 antibody (Biotin) - ab17520 from Abcam

Host Goat
Clonality Polyclonal

Anti-NAP2 antibody [EPR7767] - ab133252 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7767
Anti-NAP2 antibody [EPR7767] (ab133252) at 1/1000 dilution + Human platelet lysate at 10 µg

Anti-PPBP / CXCL7 Antibody (clone NYRhNAP-2) - LS-C204673 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone NYRhNAP-2

Anti-PPBP / CXCL7 Antibody - LS-C211366 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-PPBP / CXCL7 Antibody (Internal, clone EPR7767) - LS-C152495 from LifeSpan Bioscience

Host Rabbit
Clonality Monoclonal
Clone EPR7767
Western blot analysis on human platelet lysate using anti-PPBP antibody.

Anti-PPBP / CXCL7 Antibody (Internal, clone EPR7766) - LS-C152526 from LifeSpan Bioscience

Host Rabbit
Clonality Monoclonal
Clone EPR7766
Western blot analysis on human platelet lysate using anti-PPBP antibody.

Anti-PPBP / CXCL7 Antibody (Biotin) - LS-C211367 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-PPBP / CXCL7 Antibody (HRP) - LS-C211369 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-PPBP / CXCL7 Antibody - LS-C192870 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of extracts of mouse liver cell lines, using PPBP antibody.
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