PQBP1

Gene Symbol	PQBP1
Entrez Gene	10084
Alt Symbol	MRX2, MRX55, MRXS3, MRXS8, NPW38, RENS1, SHS
Species	Human
Gene Type	protein-coding
Description	polyglutamine binding protein 1
Other Description	38 kDa nuclear protein containing a WW domain|polyglutamine tract-binding protein 1|polyglutamine-binding protein 1
Swissprots	Q4VY36 Q4VY25 Q4VY27 O60828 Q4VY29 Q4VY34 Q9GZP2 Q4VY26 Q4VY35 Q9GZU4 Q4VY37 Q4VY30 Q9GZZ4 Q4VY38
Accessions	BAB16702 BAB16703 BAB16704 BAB16705 CAP12212 EAW50735 EAW50736 EAW50737 EAW50738 O60828 AB016533 BAA76400 AB041833 BAB16706 AB041834 BAB16707 AB041835 BAB16708 AB041836 BAB16709 AJ005893 CAA06750 AJ242829 CAB44309 AJ973593 CAJ00537 AJ973594 CAJ00538 AJ973595 CAJ00539 AJ973596 CAJ00540 AJ973597 CAJ00541 AJ973598 CAJ00542 AJ973599 CAJ00543 AJ973600 CAJ00544 AJ973601 CAJ00545 AJ973602 CAJ00546 AJ973603 CAJ00547 AJ973604 CAJ00551 AJ973605 CAJ00548 AJ973606 CAJ00549 AJ973607 CAJ00550 BC012358 AAH12358 BE385548 BE396796 BI818141 BX362311 BX369697 CD051018 CD365745 CN292761 CN292769 DQ892221 ABM83147 DQ894883 ABM85809 XM_005272571 XP_005272628 XM_005272572 XP_005272629 XM_011543884 XP_011542186 NM_001032381 NP_001027553 NM_001032382 NP_001027554 NM_001032383 NP_001027555 NM_001032384 NP_001027556 NM_001167989 NP_001161461 NM_001167990 NP_001161462 NM_001167992 NP_001161464 NM_005710 NP_005701 NM_144495 NP_652766 NM_001032385 NM_144494
Function	Probably functions as scaffold protein that is part of numerous complexes and thereby plays a role in pre-mRNA splicing, transcription regulation and neuron development. Required for normal alternative splicing of target pre-mRNA species (PubMed:23512658). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit. {ECO:0000269|PubMed:10198427, ECO:0000269|PubMed:10332029, ECO:0000269|PubMed:12062018, ECO:0000269|PubMed:20410308, ECO:0000269|PubMed:23512658}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:10198427, ECO:0000269|PubMed:10332029, ECO:0000269|PubMed:12062018, ECO:0000269|PubMed:23512658}. Nucleus speckle {ECO:0000250}. Note=Colocalizes with SRSF2 in nuclear speckles (By similarity). Colocalized with POU3F2. Colocalized with ATXN1 in nuclear inclusion bodies. {ECO:0000250}.
Tissue Specificity	Widely expressed with high level in heart, skeletal muscle, pancreas, spleen, thymus, prostate, ovary, small intestine and peripheral blood leukocytes. {ECO:0000269|PubMed:10198427, ECO:0000269|PubMed:10332029}.
Top Pathways	Spliceosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human 38 kDa nuclear protein containing a WW domain Gene - orb144837 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human-PQBP1-cDNA-Clone - DC03381 from Abgent, a WuXi AppTec company Prices $359.10 Sizes 10 µg Species Human Accession BC012358

PQBP1 - MBS1276579 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC012358

Human PQBP1 cDNA clone(NM_144495.2) - CDFG008497 from Creative Biomart Species Human Accession NM_144495.2

Human PQBP1 cDNA clone(NM_001032381.1) - CDFH014986 from Creative Biomart Species Human Accession NM_001032381.1

Human PQBP1 cDNA clone(NM_001032382.1) - CDFH014987 from Creative Biomart Species Human Accession NM_001032382.1

Human PQBP1 cDNA clone(NM_001032383.1) - CDFH014988 from Creative Biomart Species Human Accession NM_001032383.1

Human PQBP1 cDNA clone(NM_001032381.1) - CDFH014989 from Creative Biomart Species Human Accession NM_001032381.1

Human PQBP1 cDNA clone(NM_001032384.1) - CDFH014990 from Creative Biomart Species Human Accession NM_001032384.1

Human PQBP1 cDNA clone(NM_001167990.1) - CDFH014991 from Creative Biomart Species Human Accession NM_001167990.1

Human PQBP1 cDNA clone(NM_001167989.1) - CDFH014992 from Creative Biomart Species Human Accession NM_001167989.1

Human PQBP1 cDNA clone(NM_001167992.1) - CDFH014993 from Creative Biomart Species Human Accession NM_001167992.1

Human PQBP1 cDNA clone(NM_005710.2) - CDFH014994 from Creative Biomart Species Human Accession NM_005710.2

Human PQBP1 ORF Clone(NM_005710.2) - CDCR291103 from Creative Biomart Species Human Accession NM_005710.2

Human PQBP1 ORF Clone(NM_005710.2) - CDCR291104 from Creative Biomart Species Human Accession NM_005710.2

Human PQBP1 ORF Clone(NM_144495.2) - CDCR317460 from Creative Biomart Species Human Accession NM_144495.2

Human PQBP1 ORF Clone(NM_144495.2) - CDCR317461 from Creative Biomart Species Human Accession NM_144495.2

Human PQBP1 ORF Clone(NM_001032381.1) - CDCR342523 from Creative Biomart Species Human Accession NM_001032381.1

Human PQBP1 ORF Clone(NM_001032381.1) - CDCR342524 from Creative Biomart Species Human Accession NM_001032381.1

Human PQBP1 ORF Clone(NM_001032382.1) - CDCR342525 from Creative Biomart Species Human Accession NM_001032382.1

Human PQBP1 ORF Clone(NM_001032382.1) - CDCR342526 from Creative Biomart Species Human Accession NM_001032382.1

Human PQBP1 ORF Clone(NM_001032383.1) - CDCR342527 from Creative Biomart Species Human Accession NM_001032383.1

Human PQBP1 ORF Clone(NM_001032383.1) - CDCR342528 from Creative Biomart Species Human Accession NM_001032383.1

Human PQBP1 ORF Clone(NM_001032384.1) - CDCR342529 from Creative Biomart Species Human Accession NM_001032384.1

Human PQBP1 ORF Clone(NM_001032384.1) - CDCR342530 from Creative Biomart Species Human Accession NM_001032384.1

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