BIRC5

Gene Symbol BIRC5
Entrez Gene 332
Alt Symbol API4, EPR-1
Species Human
Gene Type protein-coding
Description baculoviral IAP repeat containing 5
Other Description apoptosis inhibitor 4|apoptosis inhibitor survivin|baculoviral IAP repeat-containing protein 5|survivin variant 3 alpha
Swissprots Q75SP2 Q2I3N8 Q9P2W8 Q4VGX0 B2R4R1 O15392 A2SUH6 Q53F61 Q5MGC6 Q6FHL2
Accessions AAC51660 AAV40840 CCA94579 EAW89511 EAW89512 EAW89513 EAW89514 O15392 AB028869 BAA93676 AB154416 BAD11155 AF077350 AAD34226 AI800528 AK223428 BAD97148 AK301793 BAH13555 AK311917 BAG34858 AL519719 AL547142 AM393128 CAL38006 AY830084 AAW22624 AY927772 AAY15202 BC000784 BC008718 AAH08718 BC034148 AAH34148 BC065497 AAH65497 BE537971 BG178974 BG759111 BI254058 BI520186 BM476145 BQ687404 CB112371 CR541740 CAG46540 DQ227257 ABB76601 DQ310375 ABC42341 DQ310376 ABC42342 DQ310377 ABC42343 DQ310378 ABC42344 DQ310379 ABC42345 DQ508245 ABF60110 DQ508246 ABF60111 DQ508247 ABF60112 DQ508248 ABF60113 DQ508249 ABF60114 HM625836 ADM26643 XR_243654 XR_934452 NM_001012270 NP_001012270 NM_001012271 NP_001012271 NM_001168 NP_001159
Function Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked red
Subcellular Location Cytoplasm. Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Midbody. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, localizes exclusively to the midbody. Colocalizes with AURKB at mitotic chromosomes. Acetylation at Lys-129 directs its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1- mediated nuclear export.
Tissue Specificity Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines. {ECO:0000269|PubMed:10626797, ECO:0000269|PubMed:14741722, ECO:0000269|PubMed:16329164}.
Top Pathways Colorectal cancer, Hippo signaling pathway

Survivin (71G4B7) Rabbit mAb (Alexa Fluor ® 488 Conjugate) - 2810 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone 71G4B7
Confocal immunofluorescent image of HeLa cells labeled with Survivin (71G4) Rabbit mAb (Alexa Fluor® 488 Conjugate) (green). Actin filaments have been labeled with Alexa Fluor ® 555 phalloidin (red). Blue pseudocolor = DRAQ5 ® #4084 (fluorescent DNA dye).

Survivin (71G4B7) Rabbit mAb (Alexa Fluor ® 647 Conjugate) - 2866 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone 71G4B7
Flow cytometric analysis of untreated Jurkat cells, using Survivin (71G4E) Rabbit mAb (Alexa Fluor ® 647 Conjugate) in the absence of blocking peptide (green) or in the presence of Survivin Blocking Peptide #1037 (blue), compared to a nonspecific control antibody #3452 (red).

Survivin (71G4B7) Rabbit mAb (PE Conjugate) - 5875 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone 71G4B7
Flow cytometric analysis of Jurkat cells using Survivin (71G4B7) Rabbit mAb (PE Conjugate) (green) compared to concentration-matched Rabbit (DA1E) mAb IgG XP ® Isotype Control (PE Conjugate) #5742 (red).

Survivin (71G4B7) Rabbit mAb (Biotinylated) - 4037 from Cell Signaling Technology

Host Rabbit
Clonality Monoclonal
Clone 71G4B7

Survivin (71G4B7) Rabbit mAb (Alexa Fluor ® 555 Conjugate) - 4580 from Cell Signaling Technology

Host Rabbit
Clonality Monoclonal
Clone 71G4B7

Phospho-Survivin (Thr34) (D2E11) Rabbit mAb - 8888 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2E11
Western blot analysis of HT-29 and HeLa cells, untreated or synchronized in mitosis by thymidine block (2 mM, 17 hr) followed by nocodozole treatment (100 ng/ml, 24 hr), using Phospho-Survivin (Thr34) (D2E11) Rabbit mAb (top), Survivin (71G4B7) Rabbit mAb #2808 (middle), or α-Tubulin (11H10) Rabbit mAb #2125 (lower).

Survivin (6E4) Mouse mAb - 2802 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 6E4
Western blot analysis of extracts from 293 and HeLa cells, using Survivin (6E4) Mouse mAb.

Survivin (71G4B7) Rabbit mAb - 2808 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 71G4B7
Western blot analysis of lysates from Raji (human), BaF3 (mouse) and C6 (rat) cell lines using Survivin (71G4B7E) Rabbit mAb.

Survivin Antibody - 2803 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HT29 and Jurkat cells, using Survivin Antibody.

survivin (C-19) - sc-8807 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
survivin (C-19): sc-8807. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast tumor showing cytoplasmic staining.

survivin (C-6) - sc-374616 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
survivin (C-6): sc-374616. Western blot analysis of survivin expression in HCT 116 whole cell lysate.

survivin (D-8) - sc-17779 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
survivin (D-8): sc-17779. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast tumor showing cytoplasmic staining.

survivin (FL-142) - sc-10811 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
survivin (FL-142): sc-10811. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast tumor showing cytoplasmic staining.

survivin (N-18) - sc-8806 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
survivin (N-18): sc-8806. Western blot analysis of human recombinant survivin fusion protein.

survivin (2H5H2) - sc-101433 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
survivin (2H5H2): sc-101433. Western blot analysis of human recombinant survivin protein (A) and survivin expression in survivin-GFP transfected COS-7 cells (B).

survivin (M-16) - sc-8809 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
survivin (M-16): sc-8809. Western blot analysis of survivin expression in non-transfected: sc-117752 (A) and mouse survivin transfected: sc-126065 (B) 293T whole cell lysates.

survivin (3C5B2) - sc-101432 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

survivin (A-19) - sc-8808 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
survivin (A-19): sc-8808. Western blot analysis of human recombinant survivin fusion protein.

survivin (8E2) - sc-47750 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
survivin (8E2): sc-47750. Western blot analysis of human recombinant survivin fusion protein.

survivin (SPM331) - sc-65610 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

survivin (3F343) - sc-73083 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

survivin (3F342) - sc-73082 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

p-Survivin (Thr 34) - sc-16320 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-survivin (Thr 34)-R: sc-16320-R. Western blot analysis of survivin phosphorylation in untreated (A) and lambda protein phosphatase treated (B) HL-60 whole cell lysates.

Anti-Survivin (phospho T177) antibody - ab195754 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Survivin (phospho T177) antibody (ab195754) at 1/500 dilutionLane 1 : A549 whole cell lysates with the antigen-specific peptideLane 2 : A549 whole cell lysatesLysates/proteins at 12.5 µg per lane.

Anti-Survivin antibody - ab175809 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence analysis of U2OS cells labelling Survivin with ab175809 at 1:1000. Cells were fixed with PFA and permeabilized with methanol for 2 minutes. Cells were incubated with the primary anitbody overnight at room temperature. From left to right - Survivin, CyclinB, DAPI, Merge.
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