| Gene Symbol |
POLR2I
|
| Entrez Gene |
5438
|
| Alt Symbol |
RPB9, hRPB14.5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
|
| Other Description |
DNA-directed RNA polymerase II 14.5 kDa polypeptide|DNA-directed RNA polymerase II subunit I|DNA-directed RNA polymerase II subunit RPB9|RNA polymerase II 14.5 kDa subunit|RNA polymerase II subunit B9|RPB14.5
|
| Swissprots |
B2R5J2 Q6NW05 P36954
|
| Accessions |
AAB51181 CAA80649 P36954 AK312206 BAG35139 BC017112 AAH17112 BC017860 BC067794 AAH67794 DQ893214 ABM84140 DQ896543 ABM87542 NM_006233 NP_006224
|
| Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:9852112}.
|
| Top Pathways |
Huntington's disease, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism
|
