| Gene Symbol |
NKX2-2
|
| Entrez Gene |
4821
|
| Alt Symbol |
NKX2.2, NKX2B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NK2 homeobox 2
|
| Other Description |
NK-2 homolog B|NK2 transcription factor related, locus 2|NK2 transcription factor-like protein B|homeobox protein NK-2 homolog B|homeobox protein Nkx-2.2
|
| Swissprots |
O95096
|
| Accessions |
AAC83132 AAG16976 EAX10183 O95096 BC075092 AAH75092 BC075093 AAH75093 BM314196 BQ632044 BU070383 CA772329 EU446641 ABZ92170 XM_006723566 XP_006723629 XM_011529237 XP_011527539 XR_937076 XR_937077 XR_937078 XR_937079 NM_002509 NP_002500
|
| Function |
Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}.
|
| Top Pathways |
Maturity onset diabetes of the young
|
![Western Blot: Nkx2.2 Overexpression Lysate (Adult Normal) [NBL1-13661] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Nkx2.2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5657_Nkx2.2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13661-img0002.jpg)