XPO1

Gene Symbol	XPO1
Entrez Gene	7514
Alt Symbol	CRM1, emb, exp1
Species	Human
Gene Type	protein-coding
Description	exportin 1
Other Description	chromosome region maintenance 1 homolog|chromosome region maintenance 1 protein homolog|exportin 1 (CRM1 homolog, yeast)|exportin-1|exportin-1 (required for chromosome region maintenance)
Swissprots	A6NL14 O14980 Q63HP8 A8K1K5 Q68CP3 Q99433 D6W5E2
Accessions	AAY14949 EAW99993 EAW99994 EAW99995 O14980 AK094339 AK124769 BAG54092 AK289920 BAF82609 AK299039 BAG61113 AK312426 AK316481 BAH14852 AL833550 BC032847 AAH32847 BX492941 BX643790 BX647758 CAH56174 BX954288 CR749840 CAH18695 D89729 BAA23415 DQ891271 ABM82197 Y08614 CAA69905 XM_005264544 XP_005264601 XM_005264546 XP_005264603 XM_006712094 XP_006712157 XM_011533097 XP_011531399 XM_011533098 XP_011531400 XM_011533099 XP_011531401 NM_003400 NP_003391
Function	Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely
Subcellular Location	Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus. Note=Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm.
Tissue Specificity	Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney. {ECO:0000269|PubMed:9049309, ECO:0000269|PubMed:9368044}.
Top Pathways	RNA transport, Ribosome biogenesis in eukaryotes, HTLV-I infection, Influenza A, Epstein-Barr virus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CRM1 full length protein - ab131897 from Abcam Category Protein Source Wheat germ Species Human

Human CRM1 peptide - ab25749 from Abcam Category Peptide

Human CRM1 peptide - ab41768 from Abcam Category Peptide Species Human

Human CRM1 protein fragment - ab125980 from Abcam Category Protein Source E. coli Species Human

XPO1 / CRM1 Antibody Blocking Peptide - LS-E14765 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

XPO1 / CRM1 Antibody Blocking Peptide - LS-E8383 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CRM1 Protein - H00007514-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

XPO1-Antibody-C-term-Blocking-Peptide - BP6758b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

XPO1-Antibody-C-term-Blocking-Peptide - BP6684b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

XPO1 Blocking Peptide - 33R-6744 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

XPO1 Blocking Peptide - 33R-4086 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

XPO1 / Exportin-1 - H00007514-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

XPO1 / Exportin-1 - H00007514-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

XPO1 / Exportin-1 Control Peptide - SP5155CP from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

XPO1 fusion protein - ag3488 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human XPO1, GST-tagged - XPO1-3753H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human XPO1, GST-tagged - XPO1-3754H from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Exportin 1 (XPO1) - RPC258Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Exportin 1 (XPO1) - RPC258Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Exportin-1(XPO1) ,partial - CSB-YP026221HU CSB-EP026221HU CSB-BP026221HU CSB-MP026221HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CRM1 Protein - NBP2-33381PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

XPO1 (AcK568) Blocking Peptide - abx061847 from Abbexa Category Peptide

XPO1 Peptide, Human - M34GP17586H from Creative Peptides Category Peptide Source Synthetic. Species Human

XPO1 (AcK568) Blocking Peptide - CBP7237 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Recombinant Exportin 1 (XPo1) - RPU51106 from Biomatik Category Protein Prices $165.00, $338.00, $517.00, $646.72 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

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