POLR2B

Gene Symbol POLR2B
Entrez Gene 5431
Alt Symbol POL2RB, RPB2, hRPB140
Species Human
Gene Type protein-coding
Description polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
Other Description DNA-directed RNA polymerase II 140 kDa polypeptide|DNA-directed RNA polymerase II subunit B|DNA-directed RNA polymerase II subunit RPB2|RNA polymerase II second largest subunit|RNA polymerase II subunit 2|RNA polymerase II subunit B2
Swissprots P30876 Q8IZ61 A8K1A8
Accessions AAB23139 ABX80206 EAX05519 P30876 AF055028 AAC09367 AK098271 AK289823 BAF82512 AK294901 BAG57990 AK295132 BAG58155 AK299090 BAG61152 BC023503 AAH23503 BC046499 BU619780 DC323029 X63563 CAA45124 NM_000938 NP_000929 NM_001303268 NP_001290197 NM_001303269 NP_001290198
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000269|PubMed:9852112}.
Top Pathways Huntington's disease, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism

POLR2B CRISPR/Cas9 KO Plasmid (h) - sc-402591 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR2B HDR Plasmid (h) - sc-402591-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RPB2 Double Nickase Plasmid (h) - sc-402591-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR2B Double Nickase Plasmid (h2) - sc-402591-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RPB2 CRISPR Activation Plasmid (h) - sc-402591-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR2B CRISPR Activation Plasmid (h2) - sc-402591-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RPB2 Lentiviral Activation Particles (h) - sc-402591-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR2B Lentiviral Activation Particles (h2) - sc-402591-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR2B siRNA (h) - sc-62962 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

POLR2B shRNA Plasmid (h) - sc-62962-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

POLR2B shRNA (h) Lentiviral Particles - sc-62962-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RPB2 RNAi - H00005431-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU048971 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17112 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17112 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00967 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00967

POLR2B siRNA (Human) - CRH3634 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human POLR2B (NM_000938.1) - SHH379388 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human POLR2B(NM_000938.1) - SHR127216 from Creative biogene

Category siRNA
Species Reactivities Human

POLR2B shRNA Plasmid (Human) - CHH3634 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

POLR2B miRNA 3'UTR clone - MiUTR1H-08072 from Creative biogene

Species Reactivities Human
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