A2M

Gene Symbol A2M
Entrez Gene 2
Alt Symbol A2MD, CPAMD5, FWP007, S863-7
Species Human
Gene Type protein-coding
Description alpha-2-macroglobulin
Other Description C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5|alpha-2-M
Swissprots Q13677 Q68DN2 P01023 Q59F47 Q5QTS0 Q6PN97 Q6PIY3
Accessions AAK38109 AAK38110 CAA48670 CAA77774 CCO13665 EAW88590 P01023 AB209614 BAD92851 AK307832 AK312482 AY591530 AAT02228 BC026246 AAH26246 BC040071 AAH40071 BX504041 BX647329 BX648622 CR749334 CAH18188 M11313 AAA51551 M36501 AAA51552 XM_006719056 XP_006719119 NM_000014 NP_000005
Function Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Subcellular Location Secreted {ECO:0000269|PubMed:6203908}.
Tissue Specificity Secreted in plasma. {ECO:0000269|PubMed:6203908}.
Top Pathways Complement and coagulation cascades

α-2M CRISPR/Cas9 KO Plasmid (h) - sc-402377 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

α-2M HDR Plasmid (h) - sc-402377-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

α-2M Double Nickase Plasmid (h) - sc-402377-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

α-2M Double Nickase Plasmid (h2) - sc-402377-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

α-2M CRISPR Activation Plasmid (h) - sc-402377-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

α-2M CRISPR Activation Plasmid (h2) - sc-402377-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

α-2M Lentiviral Activation Particles (h) - sc-402377-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

α-2M Lentiviral Activation Particles (h2) - sc-402377-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

α-2M siRNA (h) - sc-40297 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

α-2M shRNA Plasmid (h) - sc-40297-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

α-2M shRNA (h) Lentiviral Particles - sc-40297-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

alpha 2-Macroglobulin RNAi - H00000002-R01 from Novus Biologicals

Category siRNA
Prices $339.00, $399.00
Sizes 10 nmol, 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU095201 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2594 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2594 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

A2M siRNA (Human) - CRH0002 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

A2M - MBS8223591 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human A2M (NM_000014.4) - SHH228270 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human A2M(NM_000014.4) - SHG020269 from Creative biogene

Category siRNA
Species Reactivities Human

Human A2M siRNA - orb260504 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

A2M shRNA Plasmid (Human) - CHH0002 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

A2M miRNA 3'UTR clone - MiUTR1H-00004 from Creative biogene

Species Reactivities Human
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