NAMPT

Gene Symbol	NAMPT
Entrez Gene	10135
Alt Symbol	1110035O14Rik, PBEF, PBEF1, VF, VISFATIN
Species	Human
Gene Type	protein-coding
Description	nicotinamide phosphoribosyltransferase
Other Description	NAmPRTase|pre-B cell-enhancing factor|pre-B-cell colony enhancing factor 1|pre-B-cell colony-enhancing factor 1
Swissprots	P43490 A4D0Q9 Q3KQV0 A4D0R0 Q8WW95
Accessions	AAF19249 AAQ96862 CAM12699 CAN36300 CAV30744 CBX74360 CBX78820 EAL24399 EAL24400 EAW83382 EAW83383 EAW83384 P43490 AI299587 AK023341 AK292851 BAF85540 AK304085 BAH14102 AL832518 CAH56351 BC020691 BC072439 AAH72439 BC106046 AAI06047 BI859562 HQ447548 ADQ32034 L29050 U02020 AAA17884 XM_005250100 XP_005250157 XM_011515707 XP_011514009 NM_005746 NP_005737 NM_182790
Function	Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). {ECO:0000250|UniProtKB:Q99KQ4, ECO:0000269|PubMed:24130902}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:24130902}. Cytoplasm {ECO:0000250|UniProtKB:Q99KQ4}. Secreted {ECO:0000269|PubMed:21741723}. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum. {ECO:0000269|PubMed:21741723, ECO:0000269|PubMed:24130902}.
Tissue Specificity	Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.
Top Pathways	Nicotinate and nicotinamide metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PBEF1 cDNA (ANA10259) - ANA10259 from Aviva Systems Biology Prices $189.00 Sizes 1 µg Accession BC106046

PBEF1 cDNA (ANA10263) - ANA10263 from Aviva Systems Biology Prices $189.00 Sizes 1 µg Accession BC106046

NAMPT - MBS1274502 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC072439

Human NAMPT cDNA clone(NM_005746.2) - CDFH012145 from Creative Biomart Species Human Accession NM_005746.2

Human NAMPT ORF clone(NM_005746.2) - CDCL185426 from Creative Biomart Species Human Accession NM_005746.2

Human NAMPT ORF Clone(NM_005746.2) - CDCR291226 from Creative Biomart Species Human Accession NM_005746.2

Human NAMPT ORF Clone(NM_005746.2) - CDCR291227 from Creative Biomart Species Human Accession NM_005746.2

Human NAMPT Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged - HG10990-M-F from Sino Biological Species Human Accession NM_005746.2

Human PBEF / Visfatin / NAMPT Gene ORF cDNA clone expression plasmid, C-His tag - HG10990-M-H from Sino Biological Species Human

Human PBEF / Visfatin / NAMPT Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10990-CF from Sino Biological Species Human

Human PBEF / Visfatin / NAMPT Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10990-NF from Sino Biological Species Human

Human PBEF / Visfatin / NAMPT Gene ORF cDNA clone expression plasmid - HG10990-UT from Sino Biological Species Human

Human NAMPT ORF clone(NM_005746.2) - CDCL185426 from Creative biogene Species Human

Human NAMPT ORF Clone (BC072439) - CDCS412404 from Creative biogene Species Human Accession P43490

Human NAMPT gene - orb91532 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human NAMPT cDNA Clone(NM_005746.2) - CDFH012145 from Creative biogene Species Human

Human PBEF / Visfatin / NAMPT Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10990-ANG from Sino Biological Species Human

Human PBEF / Visfatin / NAMPT Gene ORF cDNA clone expression plasmid, C-His tag - HG10990-CH from Sino Biological Species Human

Human PBEF / Visfatin / NAMPT Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10990-ACR from Sino Biological Species Human

Human PBEF / Visfatin / NAMPT Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10990-ACG from Sino Biological Species Human

Human PBEF / Visfatin / NAMPT Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10990-CM from Sino Biological Species Human

Human PBEF / Visfatin / NAMPT Gene ORF cDNA clone in cloning vector - HG10990-U from Sino Biological Species Human

Human PBEF / Visfatin / NAMPT Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG10990-ANR from Sino Biological Species Human

Human PBEF / Visfatin / NAMPT Gene ORF cDNA clone expression plasmid, N-His tag - HG10990-NH from Sino Biological Species Human

Human PBEF / Visfatin / NAMPT Gene ORF cDNA clone expression plasmid, N-HA tag - HG10990-NY from Sino Biological Species Human

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