PSEN2

Gene Symbol	PSEN2
Entrez Gene	5664
Alt Symbol	AD3L, AD4, CMD1V, PS2, STM2
Species	Human
Gene Type	protein-coding
Description	presenilin 2
Other Description	AD3LP|AD5|Alzheimer disease 4|E5-1|PS-2|STM-2|presenilin-2
Swissprots	Q96P32 B1AP21 A8K8D4 P49810
Accessions	AAB50054 CDH92547 EAW69796 EAW69797 EAW69798 EAW69799 EAW69800 P49810 AF416718 AAL16812 AI091221 AK292299 BAF84988 AK301143 BAG62735 BC006365 AAH06365 BT006984 AAP35630 DA198818 DA915823 DQ890646 ABM81572 DQ893826 ABM84752 L43964 AAB59557 L44577 AAC42012 U34349 AAC50290 XM_005273199 XP_005273256 XM_011544236 XP_011542538 XR_949149 XR_949150 NM_000447 NP_000438 NM_012486 NP_036618
Function	Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. {ECO:0000269|PubMed:10497236, ECO:0000269|PubMed:10652302}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:8574969}; Multi-pass membrane protein {ECO:0000269|PubMed:8574969}. Golgi apparatus membrane {ECO:0000269|PubMed:8574969}; Multi-pass membrane protein {ECO:0000269|PubMed:8574969}.
Tissue Specificity	Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney. {ECO:0000269|PubMed:8574969}.
Top Pathways	Notch signaling pathway, Alzheimer's disease, Neurotrophin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rat PSEN2 / Presenilin 2 ELISA Kit (Sandwich ELISA) - LS-F8821 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.059 ng/ml Range 0.156-10 ng/ml

Human Presenilin 2 ELISA Kit - abx051956 from Abbexa Category ELISA Kit

Presenilin 2, Human, ELISA Kit - E01P0149 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Presenilin-2, PSEN2, Human, ELISA Kit - E1274h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 15.6-1000 pg/mL

Presenilin 2, PS2, Human, ELISA Kit - E-EL-H2273 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Presenilin 2, PS2, Rabbit, ELISA Kit - E-EL-RB1127 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Presenilin 2, PS2, Chicken, ELISA Kit - E-EL-Ch1743 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Presenilin 2, PS2, Porcine, ELISA Kit - E-EL-P1532 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Presenilin 2, PS2, Monkey, ELISA Kit - E-EL-MK1180 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Custom Human Presenilin 2 ELISA - ELH-PSEN2 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Presenilin 2, ELISA Kit - MBS005383 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Presenilin 2, ELISA Kit - MBS054799 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Presenilin 2, ELISA Kit - MBS753182 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Presenilin 2, ELISA Kit - MBS021033 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Presenilin 2, ELISA Kit - MBS052016 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Presenilin 2, ELISA Kit - MBS018484 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Presenilin 2, ELISA Kit - MBS035897 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Presenilin 2, ELISA Kit - MBS746812 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Presenilin 2, ELISA Kit - MBS011334 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Presenilin 2, ELISA Kit - MBS012360 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Presenilin 2, ELISA Kit - MBS032079 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Presenilin 2, ELISA Kit - MBS035162 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Presenilin 2, ELISA Kit - MBS038492 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Presenilin 2, ELISA Kit - MBS026461 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Presenilin 2, ELISA Kit - MBS015497 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Search more