NFATC1

Gene Symbol NFATC1
Entrez Gene 4772
Alt Symbol NF-ATC, NFAT2, NFATc
Species Human
Gene Type protein-coding
Description nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Other Description NFAT transcription complex cytosolic component|nuclear factor of activated T-cells, cytoplasmic 1
Swissprots Q12865 B5B2M7 B5B2M4 Q2M1S3 B5B2M9 B5B2M6 B5B2M5 O95644 Q15793 B5B2M8 B5B2N1
Accessions CBX47640 CBX47641 CBX47642 CBX47643 CBX47644 EAW66617 EAW66618 EAW66619 EAW66620 EAW66621 EAW66622 O95644 AA621079 AA679278 AK292641 BAF85330 AK293760 BAG57179 AK309546 AW014910 BC033848 BC045628 BC104753 AAI04754 BC112243 AAI12244 BC143457 BF515172 EU887559 ACG55579 EU887560 ACG55580 EU887561 ACG55581 EU887562 ACG55582 EU887563 ACG55583 EU887564 ACG55584 EU887565 ACG55585 EU887566 ACG55586 HY039825 U08015 AAA19601 U59736 AAC50869 U80917 AAD00450 U80918 AAD00451 U80919 AAD00452 X99829 CAA68146 NM_001278669 NP_001265598 NM_001278670 NP_001265599 NM_001278672 NP_001265601 NM_001278673 NP_001265602 NM_001278675 NP_001265604 NM_006162 NP_006153 NM_172387 NP_765975 NM_172388 NP_765976 NM_172389 NP_765977 NM_172390 NP_765978
Function Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:16511445}. Nucleus {ECO:0000269|PubMed:16511445}. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
Tissue Specificity Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T- cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T- cells after second antigen exposure. Isoforms IA are widely expressed but not detected in liver nor pancreas, neural expression is strongest in corpus callosum. Isoforms IB are expressed mostly in muscle, cerebellum, placenta and thymus, neural expression in fetal and adult brain, strongest in corpus callosum. {ECO:0000269|PubMed:18675896}.
Top Pathways cAMP signaling pathway, Wnt signaling pathway, Inflammatory bowel disease (IBD), cGMP-PKG signaling pathway, Oxytocin signaling pathway

NFAT2 (D15F1) Rabbit mAb - 8032 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D15F1
Western blot analysis of extracts from Jurkat and CCRF-CEM cells using NFAT2 (D15F1) Rabbit mAb.

NFATc1 (7A6) - sc-7294 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NFATc1 (7A6): sc-7294. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lymphoma showing cytoplasmic staining.

NFATc1 (H-10) - sc-17834 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NFATc1 (H-10): sc-17834. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lymph node tissue showing nuclear and cytoplasmic staining of follicle and non-follicle cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

NFATc1 (K-18) - sc-1149 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NFATc1 (K-18): sc-1149-R. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lymph node tissue showing cytoplasmic staining of cells in germinal and non-germinal centers.

NFATc1 (H-110) - sc-13033 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NFATc1 (H-110): sc-13033. Western blot analysis of NFATc1 expression in Ramos whole cell lysate.

p-NFATc1 (Ser 257) - sc-32978 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

p-NFATc1 (Thr 339) - sc-32975 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
p-NFATc1 (Thr 339): sc-32975. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lymph node tissue showing cytoplasmic staining of cells in germinal and non-germinal centers.

Anti-NFAT2 (phospho S233) antibody [EPR2376(N)] - ab180510 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2376(N)
All lanes : Anti-NFAT2 (phospho S233) antibody [EPR2376(N)] (ab180510) at 1/20000 dilutionLane 1 : Jurkat cell lysate + Calyculin ALane 2 : Jurkat cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-NFAT2 (phospho S237) antibody [EPR2377(N)] - ab183023 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2377(N)
Flow cytometry analysis of permealized 293 cells labeling NFAT2 (phospho S237) using ab183023 at 1/200 dilution (red). A Goat anti rabbit IgG (FITC) at 1/150 dilution was used as secondary antibody. Cells were fixed with 2% paraformaldehyde. Isotype control: Rabbit monoclonal IgG (green).

Anti-NFAT2 antibody - ab175134 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence analysis of U2OS cells using ab175134. Blue DAPI for nuclear staining.

Anti-NFAT2 antibody - ab124292 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NFAT2 antibody (ab124292) at 0.1 µg/mlLane 1 : 293T whole cell lysate at 50 µgLane 2 : 293T whole cell lysate at 15 µgLane 3 : Jurkat whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-NFAT2 antibody - ab134469 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NFAT2 antibody (ab134469) at 1 µg/mlLane 1 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell LysateLane 2 : Ramos (Human Burkitt's lymphoma cell line) Whole Cell LysateLane 3 : THP1 (Human acute monocytic leukemia cell line) Whole Cell Lysate Lane 4 : K562 (Human erythromyeloblastoid leukemia cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-NFAT2 antibody - ab46910 from Abcam

Prices $359.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-NFAT2 antibody - ab116568 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-NFAT2 antibody (ab116568) at 1/100 dilution + NCI H292 cell line lysate at 35 µg

Anti-NFAT2 antibody - ab98173 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-NFAT2 antibody (ab98173) at 1 µg/ml (5% skim milk / PBS buffer) + NCI-H226 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-NFAT2 antibody - ab131078 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NFAT2 antibody - ab25916 from Abcam

Prices $392.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of NFATc1 in Ramos cell lysate. Lane 1. Without blocking peptide. Lane 2. With blocking peptide.

Anti-NFAT2 antibody [7A6] - ChIP Grade - ab2796 from Abcam

Prices $404.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7A6
Immunocytochemistry/Immunofluorescence analysis of NFAT2 shows staining in 293 cells. NFAT2 (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were incubated without (control) or with ab2796 (1:20) overnight at 4°C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody. Images were taken at 60X magnification.

Anti-NFAT2 antibody [AT1C3] - ab115740 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone AT1C3
ab115740 at 10ug/ml staining NFAT2 in Human spleen tissue by immunohistochemistry (FFPE). Following primary incubation slides were incubated with biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-NFAT2 antibody [EPR2431(N)(B)] - ab177464 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2431(N)(B)
Flow cytometric analysis of permeabilized Jurkat cells labeling NFAT2  (red)  with ab177464 at 1/10 dilution, or a rabbit IgG (negative) (green).

Anti-NFATC1 Antibody (aa102-114) - LS-C9316 from LifeSpan Bioscience

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-NFATC1 / NFAT2 Antibody (aa211-223) - LS-C9317 from LifeSpan Bioscience

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-NFATC1 Antibody (aa1-654) - LS-C9319 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-NFATC1 / NFAT2 Antibody (aa102-114) - LS-C40632 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NFATC1 / NFAT2 Antibody (aa1-654) - LS-C9320 from LifeSpan Bioscience

Prices $665.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
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