| Gene Symbol | Trpa1 |
|---|---|
| Entrez Gene | 277328 |
| Alt Symbol | Anktm1, TRPA1b |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | transient receptor potential cation channel, subfamily A, member 1 |
| Other Description | ANKTM1|ankyrin-like with transmembrane domains protein 1|transient receptor potential cation channel subfamily A member 1 |
| Swissprots | Q8BLA8 Q0VBN5 |
| Accessions | EDL14331 EDL14332 Q8BLA8 AK045771 BAC32487 AY231177 AAO43183 BC120563 AAI20564 BC131963 AAI31964 KF460461 AHB62275 XM_006495526 XP_006495589 XM_011238386 XP_011236688 NM_177781 NP_808449 |
| Function | Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system. {ECO:0000269|PubMed:12654248, ECO:0000269|PubMed:15046718, ECO:0000269|PubMed:15483558, ECO:0000269|PubMed:15843607}. |
| Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Tissue Specificity | Expressed in inner ear (at protein level). Specifically expressed in a subset of nociceptive neurons. Expressed in the same neurons that TRPV1. In contrast, it is not expressed in neurons expressing TRPM8. Expressed in the superior cervical ganglion. {ECO:0000269|PubMed:12654248, ECO:0000269|PubMed:15194861, ECO:0000269|PubMed:15483558, ECO:0000269|PubMed:15843607}. |
| Top Pathways | Inflammatory mediator regulation of TRP channels |
ANKTM1 CRISPR/Cas9 KO Plasmid (m) - sc-435491 from Santa Cruz Biotechnology
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ANKTM1 HDR Plasmid (m) - sc-435491-HDR from Santa Cruz Biotechnology
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ANKTM1 Double Nickase Plasmid (m) - sc-435491-NIC from Santa Cruz Biotechnology
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ANKTM1 Double Nickase Plasmid (m2) - sc-435491-NIC-2 from Santa Cruz Biotechnology
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ANKTM1 CRISPR Activation Plasmid (m) - sc-435491-ACT from Santa Cruz Biotechnology
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ANKTM1 CRISPR Activation Plasmid (m2) - sc-435491-ACT-2 from Santa Cruz Biotechnology
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ANKTM1 Lentiviral Activation Particles (m) - sc-435491-LAC from Santa Cruz Biotechnology
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ANKTM1 Lentiviral Activation Particles (m2) - sc-435491-LAC-2 from Santa Cruz Biotechnology
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ANKTM1 siRNA (m) - sc-44781 from Santa Cruz Biotechnology
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ANKTM1 shRNA Plasmid (m) - sc-44781-SH from Santa Cruz Biotechnology
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ANKTM1 shRNA (m) Lentiviral Particles - sc-44781-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU061121 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN43524 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND43524 from Sigma-Aldrich
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TRPA1 siRNA (Mouse) - CRN4195 from Cohesion Biosciences
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TRPA1 - MBS829592 from MyBioSource
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shRNA set against Mouse Trpa1 (NM_177781.4) - SHH435516 from Creative biogene
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shRNA set against Mouse Trpa1(NM_177781.4) - SHL096636 from Creative biogene
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Mouse TRPA1 siRNA - orb293670 from Biorbyt
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TRPA1 shRNA Plasmid (Mouse) - CHN4195 from Cohesion Biosciences
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TRPA1 miRNA 3'UTR clone - MiUTR1M-12182 from Creative biogene
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