| Gene Symbol |
Il22ra1
|
| Entrez Gene |
230828
|
| Alt Symbol |
9130219A07Rik, ENSMUSG00000073746, IL-22R, Il22r
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
interleukin 22 receptor, alpha 1
|
| Other Description |
IL-22 receptor subunit alpha-1|IL-22R-alpha-1|IL-22RA1|interleukin-22 receptor alpha chain|interleukin-22 receptor subunit alpha-1
|
| Swissprots |
Q80XZ4 B2RU51 Q3URP9
|
| Accessions |
CAH61680 CAH61684 CAL60110 CAP40191 CBM42928 EDL29970 Q80XZ4 AK141289 BAE24639 AK162333 BAE36858 AY103454 AAM52222 BC140972 AAI40973 BC140973 AAI40974 NM_178257 NP_839988
|
| Function |
Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. {ECO:0000269|PubMed:12618864}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Expressed in kidney, liver and lung. {ECO:0000269|PubMed:12618864}.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
|