Trpv4

Gene Symbol Trpv4
Entrez Gene 66026
Alt Symbol Otrpc4, Vroac
Species Rat
Gene Type protein-coding
Description transient receptor potential cation channel, subfamily V, member 4
Other Description VR-OAC|osm-9-like TRP channel 4|osmosensitive transient receptor potential channel 4|transient receptor potential cation channel subfamily V member 4|transient receptor potential cation channel, subfamily 5, member 4|vanilloid receptor-related osmotically activated channel (Vroac)|vanilloid receptor-related osmotically-activated channel
Swissprots Q9ERZ8
Accessions EDM13932 EDM13933 Q9ERZ8 AF263521 AAG28027 XM_006249466 XP_006249528 NM_023970 NP_076460
Function Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13- didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (By similarity). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, adherens junction {ECO:0000250}. Note=Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum. {ECO:0000250}.
Tissue Specificity Expressed lung, spleen, kidney, testis, fat, and at very low levels in trigeminal ganglia. {ECO:0000269|PubMed:11081638}.
Top Pathways Inflammatory mediator regulation of TRP channels

Anti-TRPV4 antibody - ab63014 from Abcam

Host Sheep
Clonality Polyclonal

Anti-TRPV4 antibody produced in rabbit - T9075 from Sigma-Aldrich

Prices $580.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TRPV4: <B>Cat. No. T9075</B>: Immunohistochemical staining of Rat dorsal root ganglion (DRG) frozen sections using Anti-TRPV4 antibody. <BR/>A. TRPV4 (red) in DRG neurons. <BR/>B. Staining with Mouse Anti-Parvalbumin (green) in the same DRG section. <BR/>C. Confocal merge of TRPV4 and Parvalbumin demonstrates colocalization.

TRPV4-Antibody - AG1349 from Abgent, a WuXi AppTec company

Prices $375.00, $475.00, $575.00
Sizes 25 µl, 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of ND7/23 cell line lysate: 1. Anti-TRPV4 antibody (#AG1349), (1:200). 2. Anti-TRPV4 antibody, preincubated with the control peptide antigen.

TRPV4-extracellular-Antibody - AG1440 from Abgent, a WuXi AppTec company

Prices $375.00, $475.00, $575.00
Sizes 25 µl, 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of rat brain lysate: 1. Anti-TRPV4 (extracellular) antibody (#AG1440), (1:200). 2. Anti-TRPV4 (extracellular) antibody, preincubated with the control peptide antigen.

TRPV4 Antibody - abx116201 from Abbexa

Host Rabbit
Clonality Polyclonal

TRPV4 Polyclonal Antibody - OSR00062W from Thermo Fisher Scientific

Prices $309.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TRPV4 Antibody - OST00012W from Thermo Fisher Scientific

Prices $292.00
Sizes 100 µl
Host Sheep
Clonality Polyclonal

TRPV4 polyclonal antibody - BML-SA565-0050 from Enzo Life Sciences

Prices $345.00, $517.00
Sizes 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal

TRPV4 Antibody - CSB-PA025096GA01HU from Cusabio

Host Rabbit

TRPV4 (extracellular) Antibody - WGA1246 from WuXi Biosciences

Prices $275.00, $375.00, $475.00
Sizes 25 µl, 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of rat brain lysate: 1. Anti-TRPV4 (extracellular) antibody (#WGA1246), (1:200). 2. Anti-TRPV4 (extracellular) antibody, preincubated with the control peptide antigen.

TRPV4 Antibody - WGA1235 from WuXi Biosciences

Prices $375.00, $475.00
Sizes 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of ND7/23 cell line lysate: 1. Anti-TRPV4 antibody (#WGA1235), (1:200). 2. Anti-TRPV4 antibody, preincubated with the control peptide antigen.

TRPV4 / Vanilloid receptor-like protein 2 antibody - TA328742 from Acris Antibodies

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of ND7/23 cell line lysate: 1. Anti-TRPV4 antibody, (1:200). 2. Anti-TRPV4 antibody, preincubated with the control peptide antigen.

TRPV4 / Vanilloid receptor-like protein 2 antibody - TA328772 from Acris Antibodies

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of rat brain lysate: 1. Anti-TRPV4 (extracellular) antibody, (1:200). 2. Anti-TRPV4 (extracellular) antibody, preincubated with the control peptide antigen.
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