TTI1

Gene Symbol TTI1
Entrez Gene 9675
Alt Symbol KIAA0406, smg-10
Species Human
Gene Type protein-coding
Description TELO2 interacting protein 1
Other Description TEL2-interacting protein 1 homolog|TELO2-interacting protein 1 homolog|Tel two interacting protein 1|smg-10 homolog, nonsense mediated mRNA decay factor
Swissprots Q9H4K0 Q96A38 Q5JX67 O43156 Q9BR47 D6W4K3
Accessions EAW76047 EAW76048 EAW76049 EAW76050 O43156 AB007866 BAA23702 AK095451 AK308164 BC013121 AAH13121 BC013755 AAH13755 BC107778 AAI07779 BC131759 AAI31760 BR000854 FAA00688 BU684997 CA419121 DA652320 XM_011529112 XP_011527414 XM_011529113 XP_011527415 XM_011529114 XP_011527416 XM_011529115 XP_011527417 XR_244159 XR_936662 XR_936663 XR_936664 NM_001303457 NP_001290386 NM_014657 NP_055472
Function Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. {ECO:0000269|PubMed:20427287, ECO:0000269|PubMed:20801936, ECO:0000269|PubMed:20810650}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:23263282}.
Tissue Specificity Widely expressed.

KIAA0406 cDNA (ANA11525) - ANA11525 from Aviva Systems Biology

Prices $189.00
Sizes 1 µg
Accession BC013121

KIAA0406 cDNA (ANA11526) - ANA11526 from Aviva Systems Biology

Prices $189.00
Sizes 1 µg
Accession BC013121

KIAA0406 cDNA (ANA11527) - ANA11527 from Aviva Systems Biology

Prices $189.00
Sizes 1 µg
Accession BC013121

Human TTI1 ORF Clone(NM_014657.1) - CDCR297985 from Creative biogene

Species Human

Human TTI1 ORF Clone (BC013121) - CDCS419882 from Creative biogene

Species Human
Accession D6W4K3

Human TTI1 cDNA Clone(NM_014657.1) - CDFH020575 from Creative biogene

Species Human

Human TTI1 cDNA Clone(NM_014657.1) - CDFH020576 from Creative biogene

Species Human
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