CASQ1

Gene Symbol CASQ1
Entrez Gene 844
Alt Symbol CASQ, PDIB1, VMCQA
Species Human
Gene Type protein-coding
Description calsequestrin 1 (fast-twitch, skeletal muscle)
Other Description calmitin|calmitine|calsequestrin, skeletal muscle isoform|calsequestrin-1
Swissprots Q8TBW7 B1AKZ2 P31415 B2R863
Accessions EAW52736 P31415 AA197256 AI141895 AK300713 BAG62390 AK313250 BAG36060 BC022289 AAH22289 BF574316 BX500008 DA766051 DQ891985 ABM82911 DQ895175 ABM86101 S73775 AAB32063 NM_001231 NP_001222
Function Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. {ECO:0000269|PubMed:22337878, ECO:0000303|PubMed:22337878}.
Subcellular Location Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:P07221}. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side {ECO:0000250|UniProtKB:P07221}. Mitochondrion matrix {ECO:0000250|UniProtKB:O09165}. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. {ECO:0000250|UniProtKB:P07221}.

calsequestrin 1 (H-60) - sc-28274 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
calsequestrin 1 (H-60): sc-28274. Immunoperoxidase staining of formalin fixed, paraffin-embedded human skin tissue showing cytoplasmic staining of keratinocytes, melanocytes, epidermal cells and Langerhans cells.

calsequestrin 1 (D-10) - sc-137080 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
calsequestrin 1 (D-10): sc-137080. Western blot analysis of human recombinant calsequestrin 1 fusion protein.

calsequestrin 1 (N-16) - sc-16571 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
calsequestrin 1 (N-16): sc-16571. Immunoperoxidase staining of formalin fixed, paraffin-embedded human skeletal muscle tissue showing cytoplasmic staining of myocytes.

calsequestrin 1 (C-15) - sc-16573 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
calsequestrin 1 (C-15): sc-16573. Immunoperoxidase staining of formalin fixed, paraffin-embedded human skeletal muscle tissue showing cytoplasmic staining of myocytes.

Anti-Calsequestrin 1 [EPR15227(B)] antibody - ab191564 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15227(B)
Anti-Calsequestrin 1 [EPR15227(B)] antibody (ab191564) at 1/10000 dilution + Human skeletal muscle lysate at 20 µgSecondarygoat anti-rabbit IgG, (H+L), peroxidase conjugated at 1/1000 dilutiondeveloped using the ECL technique

Anti-Calsequestrin 1 antibody - ab126241 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Calsequestrin 1 antibody (ab126241) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

Anti-Calsequestrin 1 antibody [EPR15226(B)] - ab185220 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15226(B)
Anti-Calsequestrin 1 antibody [EPR15226(B)] (ab185220) at 1/10000 dilution + Human skeletal muscle lysate at 20 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-Calsequestrin antibody - ab3516 from Abcam

Prices $400.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/immunofluorescence analysis of C2C12 cells labeling Calsequestrin (green) with ab3516 at 1/100. Cells were ficed woth formalin and permeabilized with 0.1% Triton C-100 in TBS for 5-10 minutes and blocked with 3% BSA in PBS for 30 minutes at room temperature. Cells were incubated with the primary antibody overnight at 4°C. A DyLight-conjugated secondary antibody was used. F-actin (red) was strained with phalloidin and nuclei (blue) were stained with Hoechst or DAPI. 60X Magnification. Left - negative control.

Anti-Calsequestrin antibody - ab97474 from Abcam

Prices $387.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
IHC image of Calsequestrin staining in Human normal heart muscle formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab97474, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-Calsequestrin antibody - ab62662 from Abcam

Prices $372.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Calsequestrin antibody - ab15611 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Calsequestrin antibody (ab15611) at 1/500 dilution + purified dog cardiac calsequestrinCalsequestrin always forms high molecular weight aggregates which are unavoidable so they always show up on the top of the gel. This is common for all known anti-CSQ antibodies and has been described in many papers in the past.

Anti-CASQ1 / Calsequestrin 1 Antibody (clone 1D7) - LS-C196821 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D7
Detection limit for recombinant GST tagged CASQ1 is 1 ng/ml as a capture antibody.

Anti-CASQ1 / Calsequestrin 1 Antibody - LS-C155368 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (50 ug of whole cell lysate) A: Rat heart 10% SDS PAGE CASQ1 antibody diluted at 1:1000

Anti-CASQ1 / Calsequestrin 1 Antibody (aa36-295) - LS-C185669 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded SNU16 xenograft using Calsequestrin 1 antibody at 1:500 dilution.

Anti-CASQ1 / Calsequestrin 1 Antibody - LS-C21185 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CASQ1 / Calsequestrin 1 Antibody - LS-C21182 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-CASQ1 / Calsequestrin 1 Antibody - LS-C21183 from LifeSpan Bioscience

Prices $680.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-CASQ1 / Calsequestrin 1 Antibody (clone VIIIDI2) - LS-C84913 from LifeSpan Bioscience

Prices $770.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone VIIIDI2

Anti-CASQ1 / Calsequestrin 1 Antibody (aa164-213) - LS-C151692 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CASQ1 / Calsequestrin 1 antibody Western Blot of Fetal kidney.

Calsequestrin 1 Antibody - NBP1-31597 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Calsequestrin 1 Antibody [NBP1-31597] - Sample(30 ug whole cell lysate)A:H1299 B:HeLa S3 10% SDS PAGE, antibody diluted at 1:1000.

Calsequestrin 1 Antibody - NB120-3516 from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Calsequestrin 1 Antibody [NB120-3516] - Analysis of 25 ug of RD (Lane 1), L6 (Lane 2) and mouse heart (Lane 3) cell lysates.

Calsequestrin 1 Antibody - NBP2-15682 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Calsequestrin 1 Antibody (1D7) - H00000844-M01 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D7

Calsequestrin Polyclonal Antibody - bs-2961R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Monoclonal Anti-CASQ1 antibody produced in mouse - WH0000844M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D7
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