NEUROD1

Gene Symbol NEUROD1
Entrez Gene 4760
Alt Symbol BETA2, BHF-1, MODY6, NEUROD, bHLHa3
Species Human
Gene Type protein-coding
Description neuronal differentiation 1
Other Description basic helix-loop-helix transcription factor|beta-cell E-box transactivator 2|class A basic helix-loop-helix protein 3|neurogenic differentiation factor 1|neurogenic helix-loop-helix protein NEUROD
Swissprots Q13340 Q9UEC8 Q96TH0 Q99455 Q13562 F1T0E1 O00343 B2R9I8 Q5U095
Accessions AAA93480 AAC83145 AAY24267 BAA36519 BAA76603 BAA87605 EAX10983 Q13562 AB593068 BAJ84015 AB593069 BAJ84016 AB593070 BAJ84017 AB593071 BAJ84018 AK313799 BAG36535 BC009046 AAH09046 BM505034 BT019731 AAV38536 D82347 BAA11558 DA486317 DB472071 DN949274 DQ891560 ABM82486 DQ894747 ABM85673 GQ904713 ADM86143 U36472 AAA79702 U80578 AAC51318 NM_002500 NP_002491
Function Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By si
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:14752053}. Note=In pancreatic islet cells, shuttles to the nucleus in response to glucose stimulation (By similarity). Colocalizes with NR0B2 in the nucleus. {ECO:0000250}.
Top Pathways Maturity onset diabetes of the young

NeuroD (D90G12) Rabbit mAb - 7019 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D90G12
Western blot analysis of extracts from human cerebellum using NeuroD (D90G12) Rabbit mAb.

NeuroD (D35G2) Rabbit mAb - 4373 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D35G2
Western blot analysis of extracts from IMR-32 cells using NeuroD (D35G2) Rabbit mAb.

NeuroD Antibody - 2833 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Y79 and WERI-Rb-1 cells, using NeuroD Antibody.

Neuro D (G-12) - sc-398891 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Neuro D (G-12): sc-398891. Western blot analysis of Neuro D expression in non-transfected: sc-110760 (A) and human Neuro D transfected: sc-110985 (B) 293 whole cell lysates.

Neuro D (G-20) - sc-1086 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Neuro D (G-20): sc-1086. Western blot analysis of Neuro D expression in MM-142 nuclear extract.

Neuro D (H-76) - sc-20805 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Neuro D (H-76): sc-20805. Western blot analysis of human recombinant Neuro D fusion protein.

Neuro D (N-19) - sc-1084 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Neuro D (N-19): sc-1084. Western blot analysis of Neuro D expression in Y79 nuclear extract.

Neuro D (A-10) - sc-46684 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Neuro D (A-10): sc-46684. Immunofluorescence staining of methanol-fixed Y79 cells showing nuclear localization.

Anti-NeuroD1 (phospho S274) antibody - ab78900 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NeuroD1 (phospho S274) antibody (ab78900) at 1/500 dilutionLane 1 : extracts from HeLa cells, treated with UV (15 min) with no immunizing peptideLane 2 : extracts from HeLa cells, treated with UV (15 min) with immunizing peptide at 5 µgLysates/proteins at 10 µg per lane.

Anti-NeuroD1 antibody - ab60704 from Abcam

Prices $401.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-NeuroD1 antibody (ab60704) + IMR-32 whole cell lysate at 50 µgSecondaryGoat Anti-Mouse IgG HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-NeuroD1 antibody - ab16508 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
[A] green = ab16508 Rabbit polyclonal antibody to NeuroD1 staining (5ug/ml)) in a fixed culture of murine neurons, differentiated for 3 days, from murine neocortical precursor cells (E14). Neurons shown emanated from the site of a neurosphere (top-left corner) which was removed prior to imaging).Alexa Fluor 488 secondary goat anti-rabbit antibody was used for detection (@ 1/400). Strong punctate nuclear and diffuse cytosolic NeuroD1 labelling at is observed.[B] red = mouse monoclonal anti-MAP (microtubule marker) with goat anti-mouse Alexa Fluor 568 (1/400) secondary antibody.[C] blue = TO-PRO-3 (nuclear) staining[D] Overlay of A, B an

Anti-NeuroD1 antibody - ab69864 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NeuroD1 antibody - ab76685 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-NeuroD1 antibody (ab76685) at 1/100 dilution + HepG2 cell line lysate at 35 µg

Anti-NeuroD1 antibody - ab38552 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NeuroD1 antibody (ab38552)Lane 1 : Y79 cell lysateLane 2 : Mouse cerebellum tissue lysateLane 3 : Rat brain tissue lysateLysates/proteins at 35 µg per lane.

Anti-NeuroD1 antibody - ab79478 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NeuroD1 antibody (ab79478) at 1/500 dilutionLane 1 : HeLa cell extractsLane 2 : HeLa cell extracts with immunizing peptide at 10 µgLysates/proteins at 10 µg per lane.

Anti-NeuroD1 antibody [3H8] - ab117562 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3H8
ab117562, at 5 µg/ml, staining NeuroD1 in formalin fixed, paraffin embedded Human testis tissue by Immunohistochemistry.

Anti-NeuroD1 antibody [EPR4008] - ab109224 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4008
All lanes : Anti-NeuroD1 antibody [EPR4008] (ab109224) at 1/1000 dilutionLane 1 : Y79 lysatesLane 2 : Fetal brain lysates Lysates/proteins at 10 µg per lane.

Anti-NeuroD1 antibody [EPR4009] - ab109188 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4009
Anti-NeuroD1 antibody [EPR4009] (ab109188) at 1/1000 dilution + Y79 cell lysate at 10 µg

Anti-NEUROD1 Antibody - LS-C37544 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NEUROD1 Antibody - LS-C9245 from LifeSpan Bioscience

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-NEUROD1 Antibody - LS-C131014 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal

Anti-NEUROD1 Antibody (N-Terminus) - LS-C30858 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: Jurkat Cell Lysate

Anti-NEUROD1 Antibody (Internal, clone EPR4008) - LS-C137981 from LifeSpan Bioscience

Prices $480.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4008
Western blot analysis on (A) Y79 and (B) fetal brain lysates using anti-NeuroD1 antibody.

Anti-NEUROD1 Antibody (aa240-289) - LS-C118366 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HeLa cells, using Neuro D (Ab-274) Antibody. The lane on the right is treated with the synthesized peptide.

Anti-NEUROD1 Antibody (C-Terminus) - LS-C110246 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
NEUROD1 antibody LS-C110246 Western blot of HepG2 cell lysate.
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