RAD51C

Gene Symbol	RAD51C
Entrez Gene	5889
Alt Symbol	BROVCA3, FANCO, R51H3, RAD51L2
Species	Human
Gene Type	protein-coding
Description	RAD51 paralog C
Other Description	DNA repair protein RAD51 homolog 3|RAD51-like protein 2|yeast RAD51 homolog 3
Swissprots	Q3B783 O43503 O43502
Accessions	AAT38108 EAW94430 EAW94431 EAW94432 EAW94433 EAW94434 O43502 AA304618 AF029669 AAC39604 AF029670 AAC39605 AI424321 AI914449 AK129738 AK290487 BAF83176 AK303363 BAG64422 BC000667 BC064578 BC073161 BC093930 AAH93930 BC101485 AAI01486 BC107753 AAI07754 BC143259 BM987503 BT007339 AAP36003 CB243543 XM_006722001 XP_006722064 XM_006722002 XP_006722065 XM_006722004 XP_006722067 XM_006722005 XP_006722068 XM_011525092 XP_011523394 XM_011525093 XP_011523395 XM_011525094 XP_011523396 XR_934513 XR_934514 NM_002876 NP_002867 NM_058216 NP_478123 NR_103872 NR_103873
Function	Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD21 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response
Subcellular Location	Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=DNA damage induces an increase in nuclear levels. Accumulates in DNA damage induced nuclear foci or RAD51C foci which is formed during the S or G2 phase of cell cycle. Accumulation at DNA lesions requires the presence of NBN/NBS1, ATM and RPA.
Tissue Specificity	Expressed in a variety of tissues, with highest expression in testis, heart muscle, spleen and prostate.
Top Pathways	Homologous recombination, Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RAD51C 293T Cell Transient Overexpression Lysate(Denatured) - H00005889-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

RAD51C overexpression lysate - LY409237 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

RAD51C overexpression lysate - LY419045 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

RAD51C overexpression lysate - LY429925 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

RAD51C 293 Cell Lysate - 408908 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Rad51C Overexpression Lysate (Native) - NBP2-08061 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Rad51C Overexpression Lysate (Native) - NBP2-05796 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

RAD51C Over-expression Lysate Product - GWB-B4611E from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Rad51C Overexpression Lysate (Native) - NBP2-09954 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Rad51C Overexpression Lysate (Denatured) - H00005889-T01 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Rad51C Overexpression Lysate (Denatured) - H00005889-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human RAD51C Knockdown Stable Cell Line - CSC-DC012915 from Creative biogene Category Cell Line Species Human

Search more