FHIT

Gene Symbol	FHIT
Entrez Gene	2272
Alt Symbol	AP3Aase, FRA3B
Species	Human
Gene Type	protein-coding
Description	fragile histidine triad
Other Description	AP3A hydrolase|bis(5'-adenosyl)-triphosphatase|diadenosine 5',5'''-P1,P3-triphosphate hydrolase|dinucleosidetriphosphatase|tumor suppressor protein
Swissprots	A2IAT0 P49789 A8K1A9 Q6IU12 A2IAS9 Q45QG9 A2IAT6
Accessions	AAB52539 AAB53793 AAB84098 AAT37530 ABD93870 ABD93871 ABG02271 ABG02272 ABG02273 ABG02274 ABG02275 ABG81420 ABI15739 ABI15740 ABI15741 ABI15742 ABM65879 ABM66086 ABM66087 ABM66088 ABM66089 ABM66090 ABM66091 ABM66092 ABM66093 CAY55966 EAW65393 EAW65394 P49789 AK127931 AK289824 BAF82513 BC032336 AAH32336 BC057223 DA239143 DQ120721 AAZ23623 DQ891575 ABM82501 DQ894769 ABM85695 KJ534835 AHW56475 U46922 AAA99013 XM_011533481 XP_011531783 XM_011533482 XP_011531784 XM_011533483 XP_011531785 XM_011533484 XP_011531786 XM_011533485 XP_011531787 XM_011533486 XP_011531788 NM_001166243 NP_001159715 NM_002012 NP_002003
Function	Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'- adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low- affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor. {ECO:0000269|PubMed:12574506, ECO:0000269|PubMed:15313915, ECO:0000269|PubMed:16407838, ECO:
Subcellular Location	Cytoplasm. Mitochondrion. Nucleus.
Tissue Specificity	Low levels expressed in all tissues tested. Phospho-FHIT observed in liver and kidney, but not in brain and lung. Phospho-FHIT undetected in all tested human tumor cell lines.
Top Pathways	Small cell lung cancer, Non-small cell lung cancer, Purine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FHIT full length protein - ab38049 from Abcam Category Protein Source E. coli Species Human

Human FHIT full length protein - ab95856 from Abcam Category Protein Source E. coli Species Human

FHIT Antibody Blocking Peptide - LS-E18419 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FHIT Partial Recombinant Protein - H00002272-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human FHIT Protein - NBP1-44387 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E. coli Species Human

FHIT Recombinant Protein - P3552 from Novus Biologicals Category Protein Prices $449.00 Sizes 100 µg Species Human

FHIT Protein - GTX109141-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

FHIT Protein (OPPA01214) - OPPA01214 from Aviva Systems Biology Category Protein Prices $315.00 Sizes 2 µg Source E. Coli

FHIT Protein (OPPA02301) - OPPA02301 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human FHIT protein - orb245509 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human FHIT protein (GST Tag) - orb81120 from Biorbyt Category Protein Prices $366.00, $400.00, $612.00 Sizes 5 μg, 2 μg, 10 μg Species Human

AP3Aase protein - orb197696 from Biorbyt Category Protein Prices $255.00, $391.00, $519.00, $1,760.00 Sizes 10 μg, 50 μg, 100 μg, 500 μg Species Human

Human FHIT protein - orb81119 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Species Human

Human FHIT protein (His Tag) - orb138873 from Biorbyt Category Protein Prices $238.00, $434.00 Sizes 20 μg, 100 μg Source E. coli Species Human

FHIT Blocking Peptide - 33R-9585 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FHIT protein - 30R-3190 from Fitzgerald Category Protein Prices $210.00 Sizes 50 µg Source E.coli

FHIT protein (His tag) - 80R-1327 from Fitzgerald Category Protein Prices $220.00 Sizes 100 µg Source E.coli

FHIT Blocking Peptide - abx062619 from Abbexa Category Peptide Species Human

FHIT (1-147, His-tag) - AR09473PU-L from Acris Antibodies Category Protein Prices $695.00 Sizes 500 µg Source E. coli Species Human

FHIT (1-147, His-tag) - AR09473PU-N from Acris Antibodies Category Protein Prices $305.00 Sizes 100 µg Source E. coli Species Human

FHIT - H00002272-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

FHIT - H00002272-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

FHIT - P3552 from Acris Antibodies Category Protein Prices $430.00 Sizes 100 µg Species Human

Recombinant Human AP3Aase - 230-00600-10 from RayBiotech Category Protein Prices $110.00 Sizes 10 µg Source Escherichia coli (E.coli) Species Human

Recombinant Human AP3Aase - 230-00600-100 from RayBiotech Category Protein Prices $336.00 Sizes 100 µg Source Escherichia coli (E.coli) Species Human

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