| Gene Symbol |
Ptpn6
|
| Entrez Gene |
116689
|
| Alt Symbol |
Ptph6, Shp-1
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
protein tyrosine phosphatase, non-receptor type 6
|
| Other Description |
SH2 phosphatase 1|protein-tyrosine phosphatase SHP-1|tyrosine-protein phosphatase non-receptor type 6
|
| Swissprots |
P81718
|
| Accessions |
EDM01944 EDM01945 P81718 AF468653 AAL77056 BC099824 AAH99824 FQ232747 U77038 AAD00262 NM_053908 NP_446360
|
| Function |
Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. {ECO:0000269|PubMed:17068200}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:17068200}. Nucleus {ECO:0000269|PubMed:17068200}. Note=In neurons, translocates into the nucleus after treatment with angiotensin II. Shuttles between the cytoplasm and nucleus via its association with PDPK (By similarity). {ECO:0000250}.
|
| Top Pathways |
Adherens junction, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, B cell receptor signaling pathway
|