KCNE1

Gene Symbol KCNE1
Entrez Gene 3753
Alt Symbol ISK, JLNS, JLNS2, LQT2/5, LQT5, MinK
Species Human
Gene Type protein-coding
Description potassium channel, voltage gated subfamily E regulatory beta subunit 1
Other Description IKs producing slow voltage-gated potassium channel subunit beta Mink|cardiac delayed rectifier potassium channel protein|delayed rectifier potassium channel subunit IsK|minimal potassium channel|potassium voltage-gated channel subfamily E member 1|potassium voltage-gated channel, Isk-related family, member 1|potassium voltage-gated channel, Isk-related subfamily, member 1|voltage gated potassiun channel accessory subunit
Swissprots P15382 Q8N709 A5H1P2 Q91Z94
Accessions AAA36129 AAA63905 ABQ01238 ABS84249 ABS84252 EAX09783 P15382 AF135188 AAD25096 AI720140 AK095442 AK304336 BAG65181 AK311384 AK313543 BAG36319 AY789479 AAX11417 AY789480 AAX11418 BC036452 AAH36452 BC046224 AAH46224 BC069055 CD370857 CR541756 CAG46556 DA418828 DA806205 DB089177 DB214219 DB223354 DB230009 DB233067 EF514882 ABS84250 EF514883 ABS84251 EU008568 ABS31132 EU008569 ABS31133 EU008570 ABS31134 JF432567 ADZ15784 L28168 AAA58418 XM_011529555 XP_011527857 XM_011529556 XP_011527858 XM_011529557 XP_011527859 NM_000219 NP_000210 NM_001127668 NP_001121140 NM_001127669 NP_001121141 NM_001127670 NP_001121142 NM_001270402 NP_001257331 NM_001270403 NP_001257332 NM_001270404 NP_001257333 NM_001270405 NP_001257334
Function Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Expressed in heart, lung, kidney, testis, ovaries, small intestine, peripheral blood leukocytes. Not detected in pancreas, spleen, prostate and colon. Restrictively localized in the apical membrane portion of epithelial cells. {ECO:0000269|PubMed:9312006}.
Top Pathways Adrenergic signaling in cardiomyocytes

Human KCNE1 full length protein - ab158781 from Abcam

Category Protein
Source Wheat germ
Species Human
ab158781 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human KCNE1 protein fragment - ab158782 from Abcam

Category Protein
Source Wheat germ
Species Human
ab158782 on a 12.5% SDS-PAGE stained with Coomassie Blue.

KCNE1 peptide - ab151760 from Abcam

Category Peptide

Recombinant Human KCNE1 Protein - H00003753-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

Recombinant Human KCNE1 Protein - H00003753-P01 from Novus Biologicals

Category Protein
Prices $319.00
Sizes 2 µg
Source Wheat Germ
Species Human

KCNE1 - H00003753-P01-02 from Acris Antibodies

Category Protein
Prices $310.00
Sizes 2 µg
Source in vitro transl.
Species Human

KCNE1 - H00003753-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

KCNE1 - H00003753-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

KCNE1 fusion protein - ag3495 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Potassium voltage-gated channel subfamily E... - pep0292 from Covalab

Category Peptide
Species Human

Recombinant Human Potassium voltage-gated channel subfamily E member 1(KCNE1) - CSB-YP012025HU CSB-EP012025HU CSB-BP012025HU CSB-MP012025HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Potassium voltage-gated channel subfamily E member 1 (KCNE1), Recombinant Protein - MBS1318566 from MyBioSource

Category Protein
Prices $790.00, $790.00, $1,015.00, $1,015.00, $1,105.00, $1,105.00, $1,560.00, $1,560.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Orangutan

Potassium voltage-gated channel subfamily E member 1 (KCNE1), Recombinant Protein - MBS961475 from MyBioSource

Category Protein
Prices $1,105.00, $1,105.00, $1,560.00, $1,560.00
Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

KCNE1 Peptide, Human - M34GP07939H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Potassium voltage-gated channel subfamily E member 1, Recombinant Protein - MBS7042974 from MyBioSource

Category Protein
Prices $960.00, $1,935.00, $3,145.00
Sizes 10 µg, 50 µg, 100 µg
Source Cell Free Expression
Species Human
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