Htra1

Gene Symbol Htra1
Entrez Gene 56213
Alt Symbol AI429470, HTRA, L56, Prss11, RSPP11
Species Mouse
Gene Type protein-coding
Description HtrA serine peptidase 1
Other Description high-temperature requirement A serine peptidase 1|insulin-like growth factor binding protein 5 protease|protease, serine, 11 (Igf binding)|serine protease 11|serine protease HTRA1
Swissprots Q91WS3 Q9R118 Q9QZK6 Q8BN05 Q8BN04
Accessions EDL17688 EDL17689 Q9R118 AF172994 AAD49422 AF179369 AAD52682 AI429470 AK090320 BAC41168 AK090321 BAC41169 AK128916 AK132270 BAE21071 AK167667 BAE39716 BC013516 AAH13516 CB193609 NM_019564 NP_062510
Function Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, but it is unclear whether it leads to the proteolytic degradation of TGF-beta proteins themselves (PubMed:18551132) or not (PubMed:14973287). By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrad
Subcellular Location Secreted {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Predominantly secreted. Also found associated with the plasma membrane. {ECO:0000250}.
Tissue Specificity In the brain, mainly expressed in cortical areas both in glial cells and neurons (at protein level). In bones, deposited in the matrix, with higher level in newly formed bone compared to fully calcified bone (at protein level). Also expressed in the tendons (at protein level). In the articular cartilage, detected only in the deepest zone of the joint cartilage. Not detected in the chondrocytes of the growth plate (at protein level). In an experimental arthritis model, at early disease stages, up-regulated in articular chondrocytes in the deep layers of the cartilage (at protein level). As arthritis progresses, chondrocyte expression expands toward the surface. {ECO:0000269|PubMed:14973287, ECO:0000269|PubMed:15993670, ECO:0000269|PubMed:18551132}.

Htra1 protein - orb197745 from Biorbyt

Category Protein
Prices $298.00
Sizes 200 μl
Species Mouse

Mouse Htra1 (HEK293 Lysate) - orb197727 from Biorbyt

Category Protein
Prices $255.00
Sizes 200 μg
Species Mouse

Recombinant mouse Htra1 (HEK293 Lysate) - 230-10020 from RayBiotech

Category Protein
Source Human Embryonic Kidney 293 (HEK293) Cells
Species Mouse

Recombinant mouse Htra1 (HEK293 Supernatant) - 230-20010 from RayBiotech

Category Protein
Source Human Embryonic Kidney 293 (HEK293) Cells
Species Mouse

Recombinant Mouse Serine protease HTRA1(Htra1) - CSB-YP879501MO CSB-EP879501MO CSB-BP879501MO CSB-MP879501MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Recombinant Mouse HTRA1 Protein - HTRA1-7942M from Creative Biomart

Category Protein
Source Mammalian Cells
Species Mouse

Serine protease HTRA1 (Htra1), Recombinant Protein - MBS1446875 from MyBioSource

Category Protein
Prices $875.00, $970.00, $1,095.00, $1,175.00, $1,295.00, $1,305.00, $1,345.00, $1,390.00, $1,475.00, $1,840.00, $1,990.00, $2,030.00, $2,240.00, $2,620.00
Sizes 50 µg (E-Coli), 50 µg (Yeast), 50 µg (Baculovirus), 200 µg (E-Coli), 500 µg (E-Coli), 200 µg (Yeast), 50 µg (Mammalian-Cell), 100 µg (Baculovirus), 500 µg (Yeast), 1 mg (E-Coli), 500 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 1 mg (Baculovirus)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse

Recombinant Mouse HTRA1 Protein (141-480 aa), His-tagged - HTRA1-2578M from Creative Biomart

Category Protein
Source E. coli
Species Mouse
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