ASIC3

Gene Symbol ASIC3
Entrez Gene 9311
Alt Symbol ACCN3, DRASIC, SLNAC1, TNaC1
Species Human
Gene Type protein-coding
Description acid sensing (proton gated) ion channel 3
Other Description acid-sensing (proton-gated) ion channel 3|acid-sensing ion channel 3|amiloride-sensitive cation channel 3, testis|modulatory subunit of ASIC2a|neuronal amiloride-sensitive cation channel 3|proton-gated cation channel subunit|testis sodium channel 1
Swissprots Q9UHC4 B2R9V0 O60263 Q9UER8 O75906 Q9UHC3 Q59FN9
Accessions CAB69243 CAB69244 CAB69252 EAL24495 EAL24496 EAL24497 EAW54052 EAW54053 EAW54054 EAW54055 Q9UHC3 AB010575 BAA25897 AB209421 BAD92658 AF057711 AAC62935 AF095897 AAC64188 AF195024 AAF19817 AF195025 AAF19818 AI580095 AK128129 AK313926 BAG36647 BC030282 BC156796 AAI56797 NM_004769 NP_004760 NM_020321 NP_064717 NM_020322 NP_064718 NR_046401
Function Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. {ECO:0000269|PubMed:9744806, ECO:0000269|PubMed:9886053}.
Subcellular Location Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells (By similarity). {ECO:0000250}.
Tissue Specificity Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis. {ECO:0000269|PubMed:9571199, ECO:0000269|PubMed:9886053}.
Top Pathways Inflammatory mediator regulation of TRP channels

ASIC3 (H-87) - sc-368068 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

ASIC3 (K-13) - sc-21845 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ASIC3 (K-13): sc-21845. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing cytoplasmic staining of cells in seminiferous ducts and Leydig cells.

ASIC3 (K-22) - sc-130965 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
ASIC3 (K-22): sc-130965. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human kidney tissue showing cytoplasmic localization.

Anti-ASIC3 antibody - ab10354 from Abcam

Prices $370.00
Sizes 50 µl
Clonality Polyclonal

Anti-ASIC3 antibody - ab65697 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-ASIC3 antibody - ab49333 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin embedded sections) analysis of human kidney tissue labelling ASIC3 with ab49333 at 4-8µg/ml. Arrows indicate positively labelled epithelial cells of renal tubules. Magnification: 400X.

Anti-ASIC3 antibody - ab190638 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-ASIC3 antibody (ab190638) at 1/500 dilution + HepG2 cell lysate

Anti-ACCN3 / ASIC3 Antibody (aa55-83) - LS-C319275 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACCN3 / ASIC3 Antibody (aa53-102) - LS-C31243 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ACCN3 / ASIC3 antibody LS-C31243 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-ACCN3 / ASIC3 Antibody (aa56-73) - LS-C313073 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
WB of ACCN3 / ASIC3 antibody. Lane 1: Rat Brain Tissue Lysate. Lane 2: Rat Testis Tissue Lysate. Lane 3: U87 Cell Lysate. Lane 4: NEURO Cell Lysate. Lane 5: SMMC Cell Lysate.

Anti-ACCN3 / ASIC3 Antibody (aa55-83) - LS-C160993 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ACCN3 Antibody western blot of CEM cell line lysates (35 ug/lane). The ACCN3 antibody detected the ACCN3 protein (arrow).

Anti-ACCN3 / ASIC3 Antibody (aa285-304) - LS-C11723 from LifeSpan Bioscience

Prices $405.00
Sizes 50 µl
Host Guinea Pig
Clonality Polyclonal

Anti-ACCN3 / ASIC3 Antibody (C-Terminus) - LS-C11722 from LifeSpan Bioscience

Prices $415.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-ACCN3 / ASIC3 Antibody (C-Terminus) - LS-C11724 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-ACCN3 / ASIC3 Antibody (aa50-100) - LS-C135995 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-ACCN3 / ASIC3 Antibody (aa55-83, AP) - LS-C250654 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACCN3 / ASIC3 Antibody (aa55-83, APC) - LS-C250655 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACCN3 / ASIC3 Antibody (aa55-83, FITC) - LS-C250657 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACCN3 / ASIC3 Antibody (aa55-83, Biotin) - LS-C250656 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACCN3 / ASIC3 Antibody (aa55-83, PE) - LS-C250658 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACCN3 / ASIC3 Antibody (aa55-83, Azide-free, HRP) - LS-C250659 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PICK1 Antibody - LS-C285648 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Amiloride-sensitive cation channel 3 Antibody - H00009311-B01P-50ug from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

ASIC3a/ASIC3 Polyclonal Antibody - bs-12132R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-ASIC3a/ASIC3 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-12132R-A350 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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