ITGAM

Gene Symbol ITGAM
Entrez Gene 3684
Alt Symbol CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6
Species Human
Gene Type protein-coding
Description integrin, alpha M (complement component 3 receptor 3 subunit)
Other Description CD11 antigen-like family member B|CR-3 alpha chain|antigen CD11b (p170)|cell surface glycoprotein MAC-1 subunit alpha|integrin alpha-M|leukocyte adhesion receptor MO1|macrophage antigen alpha polypeptide|neutrophil adherence receptor alpha-M subunit
Swissprots Q4VAK0 P11215 Q4VAK2 Q4VAK1
Accessions AAA51960 AAA58410 AAB24821 CCF76944 EAW52143 EAW52144 P11215 AA436312 AK057856 AK127637 BAG54538 AY187247 AY187248 BC096346 AAH96346 BC096347 AAH96347 BC096348 AAH96348 BC099660 AAH99660 BM194233 J03925 AAA59544 J04145 AAA59903 M18044 AAA59491 XM_006721045 XP_006721108 XM_011545850 XP_011544152 XM_011545851 XP_011544153 XR_950796 NM_000632 NP_000623 NM_001145808 NP_001139280
Function Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Predominantly expressed in monocytes and granulocytes.
Top Pathways Staphylococcus aureus infection, Legionellosis, Tuberculosis, Rap1 signaling pathway, Pertussis

Integrin αM (H-61) - sc-28664 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Integrin αM (H-61): sc-28664. Western blot analysis of Integrin αM expression in mouse peripheral blood lysate.

Integrin αM (2LPM19c) - sc-20050 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of Integrin αM expression in human PBL whole cell lysate immunoprecipitated with Integrin αM (2LPM19c): sc-20050 and detected with Integrin αM (H-61): sc-28664.

Integrin αM (44) - sc-1186 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin αM (44): sc-1186. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lymphoma showing membrane and cytoplasmic localization.

Integrin αM (C-19) - sc-6612 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Integrin αM (C-19: sc-6612. Immunoperoxidase staining of formalin fixed, paraffin-embedded human spleen tissue showing cytoplasmic staining of subset of cells in red pulp.

Integrin αM (VIM12) - sc-59744 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin αM (VIM12): sc-59744. Immunoperoxidase staining of formalin fixed, paraffin-embedded human spleen tissue showing cytoplasmic staining of cells in white pulp and cells in red pulp.

Integrin αM (LM2/1) - sc-65429 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Integrin αM (ICRF44) - sc-80542 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Integrin αM (M1/70) - sc-23937 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
Integrin αM (M1/70) PE: sc-23937 PE. FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal rat IgG<sub>2b</sub>: sc-2873.

Integrin αM (2B2.38) - sc-71444 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Integrin αM (Bear-1) - sc-52686 from Santa Cruz Biotechnology

Host Mouse
Clonality Monoclonal
Integrin αM (Bear-1): sc-52686. Indirect FCM analysis of human peripheral blood leukocytes stained with Integrin αM (Bear-1), followed by PE-conjugated goat anti-mouse IgG: sc-3738. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-3877.

Integrin αM (MEM-174) - sc-51657 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
goat anti-mouse IgG<sub>2a</sub>-FITC: sc-2079. Indirect FCM analysis of human peripheral blood leukocytes stained with Integrin aM (MEM-174), followed by FITC-conju-gated goat anti-mouse IgG<sub>2a</sub>: sc-2079. Black line histo-gram represents the isotype control, normal mouse IgG<sub>2a</sub>: sc-3878. Antibody tested: Integrin aM (MEM-174): sc-51657.

Anti-CD11b antibody - ab62817 from Abcam

Prices $378.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
ab62817 (2µg/ml) staining of paraffin embedded Human Brain shows staining of microglia following steamed antigen retrieval with Tris/EDTA buffer pH 9 and HRP-staining.

Anti-CD11b antibody - ab128797 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
CD11b was immunoprecipitated using 0.5mg RAW 264.7 whole cell extract, 5µg of Rabbit polyclonal to CD11b and 50µl of protein G magnetic beads (+). No antibody was added to the control (-).The antibody was incubated under agitation with Protein G beads for 10min, RAW 264.7 whole cell extract lysate diluted in RIPA buffer was added to each sample and incubated for a further 10min under agitation.Proteins were eluted by addition of 40µl SDS loading buffer and incubated for 10min at 70°C; 10µl of each sample was separated on a SDS PAGE gel, transferred to a nitrocellulose membrane, blocked with 5% BSA and probed with ab128797.Secondary: Mouse monoclonal [SB62a] Secondary Antibody to Rabbit IgG light chain (HRP) (ab99697).Band: 170kDa, non specific bands - 42, 55 and 65kDa: We are unsure as to the identity of this extra band; CD11b

Anti-CD11b antibody - ab126891 from Abcam

Prices $370.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-CD11b antibody - ab131628 from Abcam

Prices $376.00
Sizes 100 µl
Host Chicken
Clonality Polyclonal
Immunohistochemical analysis of adult Mouse cerebral cortex sections labelling CD11b with ab131628 at 1/25 dilution.

Anti-CD11b antibody - ab134690 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CD11b antibody (ab134690) at 1/500 dilution + RAW 264.7 cell extract at 30 µg

Anti-CD11b antibody - ab75476 from Abcam

Prices $391.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CD11b antibody (ab75476) at 2 µg/ml + RAW 264.7 whole cell lysateObserved band size : ~160 kDa (why is the actual band size different from the predicted?)Additional bands at : 55 kDa. We are unsure as to the identity of these extra bands.

Anti-CD11b antibody [44] (Biotin) - ab19674 from Abcam

Prices $185.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 44

Anti-CD11b antibody [44aacb] (FITC) - ab86893 from Abcam

Prices $176.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone 44aacb
Cell surface flow cytometric analysis of human CD11b in human lymphocytes using 10&microl of ab86893. Shaded histogram represents cells without antibody; green represents isotype control; red represents anti-human CD11b antibody.

Anti-CD11b antibody [Bear-1] - ab36939 from Abcam

Prices $373.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone Bear-1

Anti-CD11b antibody [CBRM1/5] - Low endotoxin, Azide free - ab171200 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone CBRM1/5

Anti-CD11b antibody [DCIS1/18] - ab90881 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone DCIS1/18

Anti-CD11b antibody [DCIS1/18] (Allophycocyanin) - ab90943 from Abcam

Prices $376.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone DCIS1/18
ab90943 at 20µl/106 cells staining CD11b in Human normal blood, by flow cytometry

Anti-CD11b antibody [DCIS1/18] (CF405M) - ab123613 from Abcam

Prices $188.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone DCIS1/18
ab123613, at 5 µl/106 cells, staining CD11b in normal Human peripheral blood cells by Flow Cytometry (blue and green). Unstained cells shown in red.

Anti-CD11b antibody [DCIS1/18] (FITC) - ab90886 from Abcam

Prices $376.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone DCIS1/18
Flow cytometry analysis of CD11b in Normal peripheral blood (SPN) from a Human donor using ab90886 at 20 µl/106 cells.
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