UCHL1

Gene Symbol	UCHL1
Entrez Gene	7345
Alt Symbol	HEL-117, NDGOA, PARK5, PGP 9.5, PGP9.5, PGP95, Uch-L1
Species	Human
Gene Type	protein-coding
Description	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Other Description	epididymis luminal protein 117|neuron cytoplasmic protein 9.5|ubiquitin C-terminal hydrolase|ubiquitin carboxyl-terminal hydrolase isozyme L1|ubiquitin thioesterase L1
Swissprots	Q4W5K6 P09936 Q71UM0
Accessions	AAY40923 ACY95405 CAA35249 EAW92978 EAW92979 EAW92980 EAW92981 EAW92982 EAW92983 P09936 AB209038 BAD92275 AK054579 BAG51393 AK315368 BAG37761 BC000332 AAH00332 BC005117 AAH05117 BC006305 AAH06305 BC018838 BP202166 DQ891998 ABM82924 DQ895188 ABM86114 FJ224355 ACI46047 X04741 CAA28443 NM_004181 NP_004172
Function	Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. {ECO:0000269|PubMed:12408865, ECO:0000269|PubMed:9790970}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:19261853}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19261853}; Lipid-anchor {ECO:0000269|PubMed:19261853}. Note=About 30% of total UCHL1 is associated with membranes in brain.
Tissue Specificity	Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. {ECO:0000269|PubMed:14722078, ECO:0000269|PubMed:9790970}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PGP9.5 full length protein - ab53962 from Abcam Category Protein Prices $192.00 Sizes 25 µg Source E. coli Species Human

Active human PGP9.5 full length protein - ab125829 from Abcam Category Protein Source E. coli Species Human

Active human PGP9.5 full length protein - ab198431 from Abcam Category Protein Prices $359.00 Sizes 100 µg Source E. coli Species Human

Human PGP9.5 full length protein - ab75957 from Abcam Category Protein Source E. coli Species Human

Human PGP9.5 full length protein - ab82628 from Abcam Category Protein Source E. coli Species Human

Human PGP9.5 full length protein - ab185598 from Abcam Category Protein Source E. coli Species Human

Human PGP9.5 peptide - ab38203 from Abcam Category Peptide Species Human

Human PGP9.5 peptide - ab27848 from Abcam Category Peptide

Mouse PGP9.5 full length protein - ab202233 from Abcam Category Protein Source E. coli Species Mouse

Mouse PGP9.5 full length protein - ab80756 from Abcam Category Protein Source E. coli Species Mouse

UCHL1 / PGP9.5 Antibody Blocking Peptide - LS-E27431 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UCHL1 / PGP9.5 Antibody Blocking Peptide - LS-E27432 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UCHL1 / PGP9.5 Antibody Blocking Peptide - LS-E21685 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UCHL1 / PGP9.5 Antibody Blocking Peptide - LS-E21684 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UCHL1 / PGP9.5 Antibody Blocking Peptide - LS-E21577 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UCHL1 / PGP9.5 Antibody Blocking Peptide - LS-E21578 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UCHL1 / PGP9.5 Antibody Blocking Peptide - LS-E6871 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UCHL1 / PGP9.5 Antibody Blocking Peptide - LS-E6872 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UCH-L1/PGP9.5 Partial Recombinant Protein - H00007345-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Source Wheat Germ Species Human

UCH-L1/PGP9.5 Partial Recombinant Protein - H00007345-Q02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Source Wheat Germ Species Human

UCH-L1/PGP9.5 Recombinant Protein - H00007345-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Source Wheat Germ Species Human

UCH-L1/PGP9.5 Recombinant Protein - NBP2-34228 from Novus Biologicals Category Protein Prices $469.00 Sizes 100 µg Source E. coli

PGP9.5 / UCHL-1 Peptide - P0906 from Novus Biologicals Category Peptide Species Human

PGP9.5 / UCHL-1 Peptide - P0905 from Novus Biologicals Category Peptide Species Human

UCHL1-Antibody-C-term-Blocking-Peptide - BP2126e from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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