ID1

Gene Symbol ID1
Entrez Gene 3397
Alt Symbol ID, bHLHb24
Species Human
Gene Type protein-coding
Description inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
Other Description DNA-binding protein inhibitor ID-1|class B basic helix-loop-helix protein 24|dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein)|inhibitor of differentiation 1
Swissprots O00652 Q9H0Z5 Q5TE67 A8K537 Q9H109 Q16371 P41134 O00651 Q969Z7 E1P5L4 Q16377 Q5TE66
Accessions AAC13882 AAC13883 EAW76432 EAW76433 EAW76434 P41134 AI304595 AK291152 BAF83841 AK313786 BC000613 AAH00613 BC012420 AAH12420 BG546814 BI768231 BM856018 BT007443 AAP36111 D13889 BAA02988 D13890 BAA02989 DA839689 DQ891293 ABM82219 DQ893342 ABM84268 DQ894477 ABM85403 DQ896657 ABM87656 EU176458 ABW03909 EU176468 ABW03919 EU176808 ABW03609 S78825 AAB35038 S78986 AAB35037 X77956 CAA54920 NM_002165 NP_002156 NM_181353 NP_851998
Function Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus.
Top Pathways TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Rap1 signaling pathway

Id1 (C-20) - sc-488 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Id1 (C-20): sc-488. Western blot analysis of Id1 expression in HeLa nuclear extract.

Id1 (F-10) - sc-365654 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Id1 (F-10): sc-365654. Western blot analysis of Id1 expression in non-transfected: sc-117752 (A) and human Id1 transfected: sc-171632 (B) 293T whole cell lysates.

Id1 (G-7) - sc-374287 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Id1 (G-7): sc-374287. Western blot analysis of Id1 expression in non-transfected: sc-117752 (A) and human Id1 transfected: sc-171632 (B) 293T whole cell lysates.

Id1 (B-8) - sc-133104 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Id1 (B-8): sc-133104. Western blot analysis of Id1 expression in non-transfected: sc-117752 (A) and human Id1 transfected: sc-113028 (B) 293T whole cell lysates.

Id1 (B-1) - sc-133103 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Id1 (B-1): sc-133103. Western blot analysis of Id1 expression in non-transfected: sc-117752 (A) and human Id1 transfected: sc-113028 (B) 293T whole cell lysates.

Id1 (JC-FL) - sc-734 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Id1 (JC-FL): sc-734. Western blot analysis of mouse recombinant Id1 fusion protein.

Id1 (N-16) - sc-27186 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Id1 (N-16): sc-27186. Immunoperoxidase staining of formalin fixed, paraffin-embedded human hippocampus tissue showing cytoplasmic staining of neuronal cells and cytoplasmic and nuclear staining of glial cells.

Id1 (Z-8) - sc-427 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of human recombinant Id1 (A,C) and Id1 His-tagged mouse recombinant Id1 (B,D) fusion proteins. Antibodies tested include Id1 (Z-8): sc-427 (A,B) and Id1 (C-20): sc-488 (C,D).

Id1 (A-20) - sc-27187 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Id1 antibody - ab168256 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Id1 antibody (ab168256) at 1/500 dilutionLane 1 : ID1-transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-Id1 antibody - ab52998 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab52998 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab52998 at 10µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Id1 antibody - ab203202 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin/PFA-fixed paraffin-embedded human colon carcinoma tissue sections labeling Id1 with ab203202 at a 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Anti-Id1 antibody - ab192303 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Id1 antibody (ab192303)Lane 1 : HEK293T whole cell lysateLane 2 : mouse liver tissue lysateLane 3 : rat liver tissue lysate

Anti-Id1 antibody - ab199616 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Id1 antibody (ab199616) at 1/500 dilution + HepG2 cell lysate at 35 µgSecondarygoat anti-rabbit IgG H&L(HRP) at 1/5000 dilutiondeveloped using the ECL technique

Anti-Id1 antibody [2456C1a] - ab66495 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2456C1a

Anti-Id1 antibody [EPR7098] - ab134163 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7098
Anti-Id1 antibody [EPR7098] (ab134163) at 1/1000 dilution (unpurified) + HepG2 cell lysate at 10 µgSecondaryPeroxidase-conjugated goat anti-rabbit IgG (H+L) at 1/1000 dilution

Anti-Id1 antibody - N-terminal - ab200459 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-Id1 antibody - N-terminal (ab200459) at 1/1000 dilution + Mouse brain total cell extract

Anti-ID / ID1 Antibody - LS-C68338 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-ID / ID1 Antibody (clone 4D7-1A2) - LS-C197483 from LifeSpan Bioscience

Prices $355.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 4D7-1A2

Anti-ID / ID1 Antibody (aa66-93, APC) - LS-C222823 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ID / ID1 Antibody (aa66-93, AP) - LS-C222824 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ID / ID1 Antibody (aa66-93, Biotin) - LS-C222826 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ID / ID1 Antibody (aa66-93, FITC) - LS-C222827 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ID / ID1 Antibody (aa66-93, Azide-free, HRP) - LS-C222828 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ID / ID1 Antibody (aa66-93, PE) - LS-C222829 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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