| Gene Symbol | ID1 |
|---|---|
| Entrez Gene | 3397 |
| Alt Symbol | ID, bHLHb24 |
| Species | Human |
| Gene Type | protein-coding |
| Description | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
| Other Description | DNA-binding protein inhibitor ID-1|class B basic helix-loop-helix protein 24|dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein)|inhibitor of differentiation 1 |
| Swissprots | O00652 Q9H0Z5 Q5TE67 A8K537 Q9H109 Q16371 P41134 O00651 Q969Z7 E1P5L4 Q16377 Q5TE66 |
| Accessions | AAC13882 AAC13883 EAW76432 EAW76433 EAW76434 P41134 AI304595 AK291152 BAF83841 AK313786 BC000613 AAH00613 BC012420 AAH12420 BG546814 BI768231 BM856018 BT007443 AAP36111 D13889 BAA02988 D13890 BAA02989 DA839689 DQ891293 ABM82219 DQ893342 ABM84268 DQ894477 ABM85403 DQ896657 ABM87656 EU176458 ABW03909 EU176468 ABW03919 EU176808 ABW03609 S78825 AAB35038 S78986 AAB35037 X77956 CAA54920 NM_002165 NP_002156 NM_181353 NP_851998 |
| Function | Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus. |
| Top Pathways | TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Rap1 signaling pathway |