| Gene Symbol | EEF2 |
|---|---|
| Entrez Gene | 1938 |
| Alt Symbol | EEF-2, EF-2, EF2, SCA26 |
| Species | Human |
| Gene Type | protein-coding |
| Description | eukaryotic translation elongation factor 2 |
| Other Description | elongation factor 2|polypeptidyl-tRNA translocase |
| Swissprots | D6W618 P13639 Q58J86 B2RMP5 |
| Accessions | EAW69274 EAW69275 P13639 AK297398 BAG59838 AK298498 BAG60705 AK299225 BAG61260 AU118535 AY942181 AAX34409 BC006547 AAH06547 BC024689 AAH24689 BC126259 AAI26260 BC136313 AAI36314 HQ258667 ADR83418 M19997 AAA50388 X51466 CAA35829 Z11692 CAA77750 NM_001961 NP_001952 |
| Function | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. |
| Subcellular Location | Cytoplasm. Nucleus {ECO:0000269|PubMed:24648518}. Note=Phosphorylation by CSK promotes cleavage and SUMOylation-dependent nuclear translocation of the C-terminal cleavage product. {ECO:0000269|PubMed:24648518}. |
| Top Pathways | Oxytocin signaling pathway, AMPK signaling pathway |