| Gene Symbol |
Siah2
|
| Entrez Gene |
20439
|
| Alt Symbol |
AA415433, Sinh2
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
seven in absentia 2
|
| Other Description |
E3 ubiquitin-protein ligase SIAH2|mSiah2|seven in absentia homolog 2|siah-2
|
| Swissprots |
Q06986
|
| Accessions |
EDL35339 Q06986 AK139626 BAE24087 AK149316 BAE28809 BC058400 AAH58400 Z19581 CAA79632 NM_009174 NP_033200
|
| Function |
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. Promotes monoubiquitination of SNCA (By similarity). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed at low level in embryos and adults. Expressed in a specific population of germ cells within both the mouse ovary and testis. Absent in primordial oocytes but expressed in all growing oocytes, coincident with their recruitment from the pool of quiescent cells. Its level of expression increases as the oocytes mature. Expressed in Graafian follicles and in fertilized zygotes up until the two cell stage, a time of extensive maternal transcript degradation and zygotic gene activation. Expressed in the testis from postmeiotic spermatids. {ECO:0000269|PubMed:7895278, ECO:0000269|PubMed:8404535}.
|