AOC3

Gene Symbol AOC3
Entrez Gene 8639
Alt Symbol HPAO, SSAO, VAP-1, VAP1
Species Human
Gene Type protein-coding
Description amine oxidase, copper containing 3
Other Description amine oxidase, copper containing 3 (vascular adhesion protein 1)|copper amine oxidase|membrane primary amine oxidase|placenta copper monamine oxidase|semicarbazide-sensitive amine oxidase
Swissprots Q16853 Q45F94 L0L8N9 K7ESB3 B2RCI5
Accessions AAZ38716 BAB18866 EAW60897 Q16853 AF054985 AAC09346 AF067406 AAC25170 AK025727 AK315129 BAG37582 BC036368 BC050549 AAH50549 DA592022 DB250074 JX020506 AGB67480 U39447 AAC50919 XM_011525419 XP_011523721 XM_011525420 XP_011523722 XR_934584 NM_001277731 NP_001264660 NM_001277732 NP_001264661 NM_003734 NP_003725 NR_102422
Function Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis. {ECO:0000269|PubMed:17400359, ECO:0000269|PubMed:19588076, ECO:0000269|PubMed:23349812, ECO:0000269|PubMed:9653080}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:9653080}; Single-pass type II membrane protein {ECO:0000269|PubMed:9653080}.
Tissue Specificity Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed also in adipose tissue, in bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis. Isoform 2 seems to be the predominant transcript in fetal kidneys, fetal cartilage and fetal tonsils. The highest relative expression of isoform 2 occurs in skeletal muscle, heart, pancreas, kidney, and lung. {ECO:0000269|PubMed:17400359, ECO:0000269|PubMed:23349812, ECO:0000269|PubMed:9653080}.
Top Pathways Glycine, serine and threonine metabolism, Phenylalanine metabolism, Tyrosine metabolism, beta-Alanine metabolism

VAP-1 (D-1) - sc-374561 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
VAP-1 (D-1): sc-374561. Western blot analysis of VAP-1 expression in non-transfected: sc-117752 (A) and human VAP-1 transfected: sc-116189 (B) 293T whole cell lysates.

VAP-1 (C-15) - sc-13742 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
VAP-1 (C-15): sc-13742. Western blot analysis of VAP-1 expression in non-transfected: sc-117752 (A) and human VAP-1 transfected: sc-116189 (B) 293T whole cell lysates.

VAP-1 (E-10) - sc-373924 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
VAP-1 (E-10): sc-373924. Western blot analysis of VAP-1 expression in non-transfected: sc-117752 (A) and human VAP-1 transfected: sc-116189 (B) 293T whole cell lysates.

VAP-1 (E-19) - sc-13741 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
VAP-1 (E-19): sc-13741. Western blot analysis of VAP-1 expression in non-transfected: sc-117752 (A) and human VAP-1 transfected: sc-116189 (B) 293T whole cell lysates.

VAP-1 (H-43) - sc-28642 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
VAP-1 (H-43): sc-28642. Immunoperoxidase staining of formalin fixed, paraffin-embedded human smooth muscle tissue showing cytoplasmic staining of smooth muscle cells.

VAP-1 (N-13) - sc-13739 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
VAP-1 (N-13): sc-13739. Western blot analysis of VAP-1 expression in non-transfected: sc-117752 (A) and human VAP-1 transfected: sc-116189 (B) 293T whole cell lysates.

VAP-1 (TK8-14) - sc-33670 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
VAP-1 (TK8-14): sc-33670. Western blot analysis of VAP-1 expression in human lung tissue extract.

VAP-1 (A-8) - sc-166713 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
VAP-1 (A-8): sc-166713. Western blot analysis of VAP-1 expression in non-transfected: sc-117752 (A) and human VAP-1 transfected: sc-116189 (B) 293T whole cell lysates.

VAP-1 (6D828) - sc-73250 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Anti-VAP1 antibody - ab196739 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-VAP1 antibody (ab196739) at 1/500 dilutionLane 1 : mouse kidney tissue lysateLane 2 : mouse liver tissue lysateLane 3 : mouse heart tissue lysate

Anti-VAP1 antibody - ab135695 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-VAP1 antibody (ab135695) at 1/100 dilution + CEM cell line lysates at 35 µg

Anti-VAP1 antibody - ab42885 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of VAP1 staining in Human normal lung formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab42885, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-VAP1 antibody - ab187202 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-VAP1 antibody (ab187202) at 1/500 dilutionLane 1 : Mouse kidney tissue extractLane 2 : Mouse liver tissue extractLane 3 : Mouse heart tissue extract

Anti-VAP1 antibody - ab115574 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab115574, at 3.75µg/ml, staining VAP1 in Formalin-fixed, Paraffin-embedded Human Liver tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-VAP1 antibody - ab59037 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
ab59037 at 1 µg/ml staining VAP1 in Human liver tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Steamed antigen retrieval with citrate buffer pH 6 was performed. Antibody detected with AP-staining.

Anti-VAP1 antibody - ab156821 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-VAP1 antibody (ab156821) at 0.1 µg/ml + A549 cell line lysate at 35 µgdeveloped using the ECL technique

Anti-VAP1 antibody [174-5] - ab81718 from Abcam

Prices $379.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 174-5
ab81718 at 1/50 dilution staining VAP1 in human tonsil tissue section by Immunohistochemistry (frozen sections).

Anti-VAP1 antibody [EPR10027] - ab181168 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10027
Detection of Human VAP1 by Western Blot of Immunoprecipitate. Human small intestine lysate loaded, ab181168 used for blotting immunoprecipitated VAP1 at a 1/50 dilution. Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated secondary used at a 1/1000 dilution.

Anti-AOC3 / VAP-1 Antibody (Extracellular Domain) - LS-C40118 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-AOC3 / VAP-1 Antibody (aa27-763) - LS-C40117 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-AOC3 / VAP-1 Antibody - LS-C126461 from LifeSpan Bioscience

Prices $740.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-AOC3 / VAP-1 Antibody (Internal, APC) - LS-C206959 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AOC3 / VAP-1 Antibody (Internal, AP) - LS-C206960 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AOC3 / VAP-1 Antibody (Internal, FITC) - LS-C206962 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AOC3 / VAP-1 Antibody (Internal, Biotin) - LS-C206961 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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