| Gene Symbol |
PI4KA
|
| Entrez Gene |
5297
|
| Alt Symbol |
PI4K-ALPHA, PIK4CA, pi4K230
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphatidylinositol 4-kinase, catalytic, alpha
|
| Other Description |
PI4-kinase alpha|phosphatidylinositol 4-kinase 230|phosphatidylinositol 4-kinase alpha|phosphatidylinositol 4-kinase, type III, alpha|ptdIns-4-kinase alpha
|
| Swissprots |
P42356 Q7Z625 Q9UPG2
|
| Accessions |
P42356 AB210002 BAE06084 AF012872 AAD13352 AK094594 AK095811 BAG53136 AK124692 AK131431 AK302424 BAG63727 AK314781 BAG37317 AL048955 BC018120 AAH18120 BC046202 BC053654 AAH53654 BC172398 AAI72398 BU685224 DA959365 L36151 AAA56839 XM_005261634 XP_005261691 XM_005261635 XP_005261692 XM_011530226 XP_011528528 XM_011530227 XP_011528529 XM_011530228 XP_011528530 XR_937868 NM_058004 NP_477352 NM_002650
|
| Function |
Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Associates with the membranes of Golgi vesicles and vacuoles. {ECO:0000250}.
|
| Tissue Specificity |
Expressed ubiquitously. Highest levels in placenta and brain. Little or no expression in lung, liver, pancreas, testis or leukocytes. {ECO:0000269|PubMed:10101268, ECO:0000269|PubMed:7961848}.
|
| Top Pathways |
Inositol phosphate metabolism, Phosphatidylinositol signaling system
|