SLC3A2
| Gene Symbol | SLC3A2 |
|---|---|
| Entrez Gene | 6520 |
| Alt Symbol | 4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE |
| Species | Human |
| Gene Type | protein-coding |
| Description | solute carrier family 3 (amino acid transporter heavy chain), member 2 |
| Other Description | 4F2 cell-surface antigen heavy chain|CD98 heavy chain|antigen defined by monoclonal antibody 4F2, heavy chain|antigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43|lymphocyte activation antigen 4F2 large subunit|monoclonal antibody 44D7|solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2|solute carrier family 3 member 2 |
| Swissprots | P08195 Q13543 |
| Accessions | AAA35489 EAW74118 EAW74119 EAW74120 EAW74121 EAW74122 EAW74123 P08195 AA594112 AB018010 BAA84649 AF055031 AK025584 AK090758 AK094620 AK225304 AK304497 BAG65305 AK304685 BAG65456 AK308797 AK311592 AU143131 BC001061 AAH01061 BC003000 AAH03000 BE018712 BQ128156 BU556953 BX362778 BX443653 CA453972 CB138799 CB151304 CN302816 DC395235 EU832612 ACE87703 EU832683 ACE87015 J02769 AAA51540 J02939 AAA52497 J03569 AAA35536 NM_001012662 NP_001012680 NM_001012664 NP_001012682 NM_001013251 NP_001013269 NM_002394 NP_002385 NR_037193 NM_001012661 NM_001012663 |
| Function | Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocys |
| Subcellular Location | Apical cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localized to the plasma membrane when associated with SLC7A5 or SLC7A8. Localized to the placental apical membrane. Located selectively at cell-cell adhesion sites (By similarity). Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta was significantly stronger at full-term than at the mid- trimester stage. Expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. Also expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line C2BBe1. {ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:16496379, ECO:0000269|PubMed:3265470, ECO:0000269|PubMed:3480538}. |
| Top Pathways | Protein digestion and absorption |
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