| Gene Symbol | RPL13A |
|---|---|
| Entrez Gene | 23521 |
| Alt Symbol | L13A, TSTA1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ribosomal protein L13a |
| Other Description | 23 kDa highly basic protein|60S ribosomal protein L13a|tissue specific transplantation antigen 1 |
| Swissprots | P40429 A8K505 |
| Accessions | BAA88214 EAW52495 EAW52496 P40429 AB082924 BAC16800 AK056837 AK130605 AK222747 BAD96467 AK291120 BAF83809 AK297859 BAG60190 BC000514 AAH00514 BC000847 BC001675 AAH01675 BC001836 AAH01836 BC004900 AAH04900 BC013230 BC032107 BC062537 AAH62537 BC065236 AAH65236 BC070223 AAH70223 BC071929 AAH71929 BC105605 AAI05606 BG536330 BQ069994 EU831455 ACE87142 EU831542 ACE86461 HQ447707 ADQ32192 X56932 CAA40254 NM_001270491 NP_001257420 NM_012423 NP_036555 NR_073024 |
| Function | Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA. {ECO:0000269|PubMed:14567916, ECO:0000269|PubMed:17218275, ECO:0000269|PubMed:17921318, ECO:0000269|PubMed:23071094}. |
| Subcellular Location | Cytoplasm {ECO:0000305|PubMed:14567916}. |
| Top Pathways | Ribosome |