| Gene Symbol | LRP6 |
|---|---|
| Entrez Gene | 4040 |
| Alt Symbol | ADCAD2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | low density lipoprotein receptor-related protein 6 |
| Other Description | LRP-6|low-density lipoprotein receptor-related protein 6 |
| Swissprots | O75581 Q17RZ2 |
| Accessions | AAD21410 CCF76957 CDM49020 EAW96253 O75581 AA126261 AB209683 BAD92920 AF074264 AAC33006 AK074543 BAG51971 AK074902 BAG52027 AK094666 AK124760 BC029941 BC117136 AAI17137 BC126405 AAI26406 BC143725 AAI43726 BP229563 XM_006719078 XP_006719141 XM_011520671 XP_011518973 XM_011548873 XP_011547175 XM_011548874 XP_011547176 XR_429034 XR_429035 XR_953254 XR_953255 NM_002336 NP_002327 |
| Function | Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity). {ECO:0000250}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Note=On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD (By similarity). {ECO:0000250}. |
| Tissue Specificity | Widely coexpressed with LRP5 during embryogenesis and in adult tissues. |
| Top Pathways | Wnt signaling pathway |
Human LRP6 ELISA Kit (Sandwich ELISA) - LS-F6972 from LifeSpan Bioscience
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Human LRP-6 ELISA Kit - abx054844 from Abbexa
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Human LRP6 ELISA Kit - abx152235 from Abbexa
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Low Density Lipoprotein Receptor Related Protein 6 (LRP6), Human, ELISA Kit - SED105Hu from ARP American Research Products
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Low-density lipoprotein receptor-related protein 6, LRP6, Human, ELISA Kit - E1010h from ARP American Research Products
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Low-density lipoprotein-receptor-related protein, LRP-6, Human, ELISA Kit - CSB-E08952h from ARP American Research Products
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Low Density Lipoprotein Receptor Related Protein, LRP6, Human, ELISA Kit - E-EL-H1212 from ARP American Research Products
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Low Density Lipoprotein Receptor Related Protein, LRP6, Rabbit, ELISA Kit - E-EL-RB0348 from ARP American Research Products
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Low Density Lipoprotein Receptor Related Protein, LRP6, Chicken, ELISA Kit - E-EL-Ch0345 from ARP American Research Products
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Low Density Lipoprotein Receptor Related Protein, LRP6, Porcine, ELISA Kit - E-EL-P0340 from ARP American Research Products
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Low Density Lipoprotein Receptor Related Protein, LRP6, Sheep, ELISA Kit - E-EL-S0179 from ARP American Research Products
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Low Density Lipoprotein Receptor Related Protein, LRP6, Monkey, ELISA Kit - E-EL-MK1729 from ARP American Research Products
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Custom Human LRP-6 ELISA - ELH-LRP6 from RayBiotech
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Human LRP6 ELISA Kit - HL0286 from NeoScientific
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Anserine LRP6 ELISA Kit - AL0286 from NeoScientific
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Low-Density Lipoprotein-Receptor-Related Protein 6, ELISA Kit - MBS015108 from MyBioSource
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Low-density lipoprotein-receptor-related protein 6, ELISA Kit - MBS736293 from MyBioSource
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Low-Density Lipoprotein-Receptor-Related Protein 6, ELISA Kit - MBS028217 from MyBioSource
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Low-density lipoprotein-receptor-related protein 6, ELISA Kit - MBS738371 from MyBioSource
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Low-Density Lipoprotein-Receptor-Related Protein 6, ELISA Kit - MBS098883 from MyBioSource
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Low-Density Lipoprotein-Receptor-Related Protein 6, ELISA Kit - MBS026956 from MyBioSource
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Low-Density Lipoprotein-Receptor-Related Protein 6, ELISA Kit - MBS013400 from MyBioSource
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Low-density lipoprotein-receptor-related protein 6, ELISA Kit - MBS739416 from MyBioSource
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Low-density lipoprotein-receptor-related protein 6, ELISA Kit - MBS729443 from MyBioSource
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Low-Density Lipoprotein-Receptor-Related Protein 6, ELISA Kit - MBS069220 from MyBioSource
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