RBPJ
| Gene Symbol | RBPJ |
|---|---|
| Entrez Gene | 3516 |
| Alt Symbol | AOS3, CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH, csl |
| Species | Human |
| Gene Type | protein-coding |
| Description | recombination signal binding protein for immunoglobulin kappa J region |
| Other Description | CBF-1|H-2K binding factor-2|RBP-J kappa|RBP-JK|immunoglobulin kappa J region recombination signal binding protein 1|recombining binding protein suppressor of hairless|renal carcinoma antigen NY-REN-30|suppressor of hairless homolog |
| Swissprots | Q6P1N3 B4DY22 Q06330 Q5XKH9 |
| Accessions | AAA91836 CCQ43315 EAW92846 EAW92847 EAW92848 EAW92849 Q06330 AF086058 AK056944 AK126357 AK302230 BAG63584 AK303244 BAH13924 AK311419 AL600045 BC020780 AAH20780 BC053531 BC053568 BC064976 AAH64976 BE269143 BM472788 BM555733 BM560796 BM680668 BQ216033 CD653684 D14041 BAA21773 DC361185 DC389691 EU446485 ABZ92014 EU832795 ACE87806 GQ129335 ACT64469 L07872 AAA60258 L07874 AAA16253 L07875 AAA16254 L07876 AAA16356 Z36843 XM_005248161 XP_005248218 XM_006713963 XP_006714026 XM_011513840 XP_011512142 XM_011513841 XP_011512143 NM_005349 NP_005340 NM_015874 NP_056958 NM_203283 NP_976028 NM_203284 NP_976029 |
| Function | Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. {ECO:0000269|PubMed:21991380}. |
| Subcellular Location | Nucleus. Cytoplasm. Note=Mainly nuclear, upon interaction with RITA/C12orf52, translocates to the cytoplasm, down-regulating the Notch signaling pathway. |
| Top Pathways | Notch signaling pathway, Viral carcinogenesis, Epstein-Barr virus infection |
Human RBPJK peptide - ab26982 from Abcam
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Human RBPJK peptide - ab26983 from Abcam
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RBPJ Antibody Blocking Peptide - LS-E5001 from LifeSpan Bioscience
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RBPJ Antibody Blocking Peptide - LS-E18409 from LifeSpan Bioscience
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csl/RBPJK Partial Recombinant Protein - H00003516-Q01 from Novus Biologicals
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csl/RBPJK Recombinant Protein - H00003516-P01 from Novus Biologicals
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RBPJ-Antibody-N-term-Blocking-Peptide - BP17401a from Abgent, a WuXi AppTec company
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RBP-J kappa / RBPJ - H00003516-Q01-10 from Acris Antibodies
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RBP-J kappa / RBPJ - H00003516-Q01-25 from Acris Antibodies
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RBPJ fusion protein - Ag6206 from Proteintech Group
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RBPJ fusion protein - Ag6302 from Proteintech Group
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Recombinant Human RBPJ, His-tagged - RBPJ-31301TH from Creative Biomart
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Recombinant Human RBPJ, GST-tagged - RBPJ-2225H from Creative Biomart
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RBP-J kappa / RBPJ (transcript variant 3) - TP304791 from Acris Antibodies
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RBP-J kappa / RBPJ (transcript variant 4) - TP309094 from Acris Antibodies
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RBP-J kappa / RBPJ (full length, N-term HIS tag, transcript variant 1) - TP760429 from Acris Antibodies
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RBPJ Peptide, Human - M34GP13099H from Creative Peptides
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RBPJ Antibody - SH-A15157 from Novatein Biosciences
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csl/RBPJK Recombinant Protein Antigen - NBP2-56071PEP from Novus Biologicals
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