FOLH1

Gene Symbol	FOLH1
Entrez Gene	2346
Alt Symbol	FGCP, FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA, mGCP
Species	Human
Gene Type	protein-coding
Description	folate hydrolase (prostate-specific membrane antigen) 1
Other Description	N-acetylated alpha-linked acidic dipeptidase 1|N-acetylated-alpha-linked acidic dipeptidase I|NAALADase I|cell growth-inhibiting gene 27 protein|folylpoly-gamma-glutamate carboxypeptidase|glutamate carboxylase II|glutamate carboxypeptidase 2|glutamate carboxypeptidase II|membrane glutamate carboxypeptidase|prostate specific membrane antigen variant F|pteroylpoly-gamma-glutamate carboxypeptidase
Swissprots	B7Z312 E9PDX8 A9CB79 D3DQS5 A4UU12 Q04609 Q9P1P8 Q9NYE2 Q8TAY3 B7Z343 Q541A4 O43748 Q16305 Q9NP15
Accessions	AAC83972 AAF31167 AAP86290 CAM36419 CAM55906 CAM55926 CCA94569 EAW67858 EAW67861 Q04609 AF027824 AF176574 AAD51121 AF254357 AAF71357 AF254358 AAF71358 AJ007318 AK295368 BAH12048 AK295470 BAH12079 AK300532 BAH13299 AK312366 BAG35284 AY101595 AAM34479 BC025672 AAH25672 BC108719 AAI08720 DQ088979 AAZ66619 DQ891167 ABM82093 DQ894349 ABM85275 EF488811 ABO93402 EF488812 ABO93403 M99487 AAA60209 S76978 AAB33750 XM_011519958 XP_011518260 NM_001014986 NP_001014986 NM_001193471 NP_001180400 NM_001193472 NP_001180401 NM_001193473 NP_001180402 NM_004476 NP_004467
Function	Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N- aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:9809977}; Single-pass type II membrane protein {ECO:0000269|PubMed:9809977}.
Tissue Specificity	Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney. Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-2 is also found in normal prostate as well as in brain and liver. Isoform PSMA-9 is specifically expressed in prostate cancer. {ECO:0000269|PubMed:14716746, ECO:0000269|PubMed:16555021, ECO:0000269|PubMed:17150306, ECO:0000269|PubMed:9375657}.
Top Pathways	Vitamin digestion and absorption, Alanine, aspartate and glutamate metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human GCP2 ELISA Kit - abx151635 from Abbexa Category ELISA Kit Sensitivity 12.6 pg/ml Range 31.25 pg/ml - 2000 pg/ml

Glutamate carboxypeptidase 2 (FOLH1), Human, ELISA Kit - CSB-EL008782HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 9.75 pg/ml Range 39 pg/ml-2500 pg/ml

Glutamate carboxypeptidase 2 (FOLH1), Human, ELISA Kit - E01G0408 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Human GCP2 ELISA Kit - HG0116 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine GCP2 ELISA Kit - AG0116 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

folate hydrolase (prostate-specific membrane antigen) 1, ELISA Kit - MBS901525 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human FOLH1 is typically less than 1.2 ng/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 4.7 ng/ml -300 ng/ml.

Glutamate carboxypeptidase 2, ELISA Kit - MBS281835 from MyBioSource Category ELISA Kit Prices $465.00, $790.00, $3,500.00, $6,655.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Glutamate carboxypeptidase 2 (FOLH1), ELISA Kit - MBS7214378 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Glutamate carboxypeptidase 2 (FOLH1), ELISA Kit - MBS7214646 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Glutamate carboxypeptidase 2 (FOLH1), ELISA Kit - MBS7247933 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Glutamate carboxypeptidase 2 (FOLH1), ELISA Kit - MBS7250255 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Glutamate carboxypeptidase 2 (FOLH1), ELISA Kit - MBS7250305 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Glutamate carboxypeptidase 2 (FOLH1), ELISA Kit - MBS7203972 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Glutamate carboxypeptidase 2 (FOLH1), ELISA Kit - MBS7231877 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Glutamate carboxypeptidase 2 (FOLH1), ELISA Kit - MBS7251595 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/mL.

Glutamate carboxypeptidase 2 (FOLH1), ELISA Kit - MBS7245461 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Glutamate carboxypeptidase 2 (FOLH1), ELISA Kit - MBS7238614 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/mL.

Glutamate carboxypeptidase 2 (FOLH1), ELISA Kit - MBS7245531 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Glutamate carboxypeptidase 2 (FOLH1), ELISA Kit - MBS7250412 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL

PSMA, ELISA Kit - MBS2515718 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 2.813ng/mL Range 4.688-300ng/mL

Human Glutamate carboxypeptidase 2(FOLH1) ELISA kit - CSB-EL008782HU from Cusabio Category ELISA Kit Sensitivity 1.2 ng/ml Range 4.7 ng/ml-300 ng/ml

Human Granulocyte Chemotactic Protein 2 ELISA - E01G0109 from BlueGene Biotech Category ELISA Kit Sensitivity 1.0 pg/mL

Goat Granulocyte Chemotactic Protein 2 ELISA - E06G0109 from BlueGene Biotech Category ELISA Kit

Human PSMA(Prostate specific membrane antigen) ELISA Kit - E-EL-H5413 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 2.81 ng/mLng/mL Range 4.69~300 ng/mL

Human FOLH1 / PSMA ELISA Kit (Sandwich ELISA) - LS-F22490 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 4.69 ng/ml Range 4.69-300 ng/ml

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