Sirt2

Gene Symbol Sirt2
Entrez Gene 361532
Alt Symbol -
Species Rat
Gene Type protein-coding
Description sirtuin 2
Other Description 5E5 antigen|NAD-dependent deacetylase sirtuin-2|NAD-dependent protein deacetylase sirtuin-2|SIR2-like protein 2|regulatory protein SIR2 homolog 2
Swissprots Q5RJQ4
Accessions EDM07874 EDM07875 Q5RJQ4 BC086545 AAH86545 FQ212805 FQ216424 XM_006228672 XP_006228734 XM_006228673 XP_006228735 XM_006228675 XP_006228737 XM_006228676 XP_006228738 NM_001008368 NP_001008369
Function NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtubule stress agents, and hence allowing proper inheritance of chromosomes. Positively regulates the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex activity by deacetylating CDC20 and FZR1, then allowing progression through mitosis. Associates with both chromatin at transcriptional start sites (TSSs) and enhancers of active genes. Plays a role in cell cycle and chromatin compaction through epigenetic modulation of the regulation
Subcellular Location Nucleus {ECO:0000250}. Cytoplasm. Cytoplasm, perinuclear region. Perikaryon. Myelin membrane. Cell projection. Cytoplasm, cytoskeleton. Cell projection, growth cone {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Chromosome {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. Midbody {ECO:0000250}. Note=Localizes in the cytoplasm during most of the cell cycle except in the G2/M transition and during mitosis, where it is localized in association with chromatin and induces deacetylation of histone at 'Lys-16' (H4K16ac). Colocalizes with CDK1 at centrosome during prophase and splindle fibers during metaphase. Colocalizes with Aurora kinase AURKA in centrioles during early prophase and growing mitotic spindle throughout metaphase. Colocalizes with Aurora kinase AURKB during cytokinesis with the midbody. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins. Shuttles between the
Tissue Specificity Expressed in the cerebellum, cerebral cortex and cervival spinal cord. Expressed in Purkinje cells, oligodendrocytes and Schwann cells (at protein level). Expressed in the central nervous system (CNS). {ECO:0000269|PubMed:17344398, ECO:0000269|PubMed:21949390}.

NAD-dependent deacetylase sirtuin-2, Sirt2, Rat, ELISA Kit - E0430r from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t
Range 0.312-20 ng/mL

sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) , ELISA Kit - MBS9318284 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sirtuin 2, ELISA Kit - MBS079814 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Sirtuin 2 (SIRT2) - SEA430Ra from Cloud-clone

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.54ng/mL.
Range 1.563-100ng/mL The standard curve concentrations used for the ELISA's were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL

Rat NAD-dependent deacetylase sirtuin-2 ELISA Kit - abx256277 from Abbexa

Category ELISA Kit
Range 0.312 ng/ml - 20 ng/ml

Rat Sirtuin 2 ELISA Kit - abx156878 from Abbexa

Category ELISA Kit
Range 1.56 ng/ml - 100 ng/ml

Rat Sirtuin 2 (SIRT2) ELISA Kit - EKU08999 from Biomatik

Category ELISA Kit
Prices $718.00, $3,196.00, $5,817.00
Sizes 96 t, 5x96t, 10x96t
Sensitivity 0.54 ng/mL
Range 1.56-100 ng/mL

Rat NAD-dependent deacetylase sirtuin-2 ELISA Kit - EKE53034 from Biomatik

Category ELISA Kit
Prices $685.40, $2,912.95, $5,483.20
Sizes 96 t, 5x96t, 10x96t
Range 0.312-20 ng/mL

Sirt2 - EKR0598 from Nordic BioSite

Sensitivity 0.188ng/ml
Range 0.312-20ng/ml

Sirt2 - EKR598 from Nordic BioSite

Sensitivity 0.188ng/ml
Range 0.312-20ng/ml

Rat 5E5 antigen ELISA Kit - E073988 from Biobool

Category ELISA Kit

Rat Sirt2 ELISA Kit - E097941 from Biobool

Category ELISA Kit

SIRT2 ELISA Kit (Rat) (OKEH03114) - OKEH03114 from Aviva Systems Biology

Category ELISA Kit
Prices $425.00
Sizes 96 wells
Sensitivity 0.156 ng/mL
Range 0.312 - 20 ng/mL

Rat NAD-dependent deacetylase sirtuin-2 ELISA Kit - EK1750 from Signalway Antibody

Category ELISA Kit
Prices $599.00
Sizes 1x96t
Range 0.312-20 ng/mL

NAD-dependent deacetylase sirtuin-2, ELISA Kit - MBS2881347 from MyBioSource

Category ELISA Kit
Prices $380.00, $500.00, $2,170.00, $3,840.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Range 0.312-20 ng/mL

NAD-dependent deacetylase sirtuin-2, ELISA Kit - MBS765787 from MyBioSource

Category ELISA Kit
Prices $295.00, $390.00, $1,615.00, $3,015.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.188ng/ml
Range 0.312-20ng/ml

NAD-dependent deacetylase sirtuin-2, ELISA Kit - MBS9425610 from MyBioSource

Category ELISA Kit
Prices $555.00
Sizes 96 tests
Range 0.312-20 ng/mL

Sirtuin 1 (SIRT1), ELISA Kit - MBS450051 from MyBioSource

Category ELISA Kit
Prices $440.00, $585.00, $2,595.00, $5,040.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.118ng/mL
Range 0.312-20ng/mL

Sirtuin 2 (SIRT2) , ELISA Kit - MBS2087367 from MyBioSource

Category ELISA Kit
Prices $515.00, $780.00, $1,075.00, $4,475.00, $8,065.00
Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.66ng/mL
Range 1.56-100ng/mL
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