| Gene Symbol | Erbb4 |
|---|---|
| Entrez Gene | 59323 |
| Alt Symbol | - |
| Species | Rat |
| Gene Type | protein-coding |
| Description | v-erb-b2 avian erythroblastic leukemia viral oncogene 4 |
| Other Description | c-erbB-4|proto-oncogene-like protein c-ErbB-4|receptor tyrosine kinase|receptor tyrosine-protein kinase erbB-4|v-erb-a erythroblastic leukemia viral oncogene homolog 4 |
| Swissprots | Q62956 Q6UA29 Q9Z2N7 Q6UA28 |
| Accessions | EDL75278 EDL75279 Q62956 AF041838 AAD08899 AY375306 AAQ77348 AY375307 AAQ77349 AY375308 AAQ77350 U52531 AAC53051 NM_021687 NP_067719 |
| Function | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alter |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:12716924, ECO:0000269|PubMed:17250808}; Single-pass type I membrane protein {ECO:0000269|PubMed:12716924, ECO:0000269|PubMed:17250808}. Note=In response to NRG1 treatment, the activated receptor is internalized. |
| Tissue Specificity | Preferentially expressed in the developing nervous system. Exhibits distinct and highly regionalized patterns of expression in the adult brain, where it is mainly found in the reticular nucleus of the thalamus. Very low levels in kidney, and heart. |
| Top Pathways | ErbB signaling pathway, Calcium signaling pathway, Endocytosis, Proteoglycans in cancer |