| Gene Symbol |
CD84
|
| Entrez Gene |
8832
|
| Alt Symbol |
LY9B, SLAMF5, hCD84, mCD84
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CD84 molecule
|
| Other Description |
CD84 antigen (leukocyte antigen)|SLAM family member 5|cell surface antigen MAX.3|hly9-beta|leucocyte differentiation antigen CD84|leukocyte antigen CD84|leukocyte differentiation antigen CD84|signaling lymphocytic activation molecule 5
|
| Swissprots |
Q9UIB7 Q6FHA8 Q9UIB6 O95660 B2R8T1 Q9UF04 B7Z3R8 Q9UIT7 Q5H9R1 Q8WWI8 Q9UIB8 O95266 Q8WLP1 O15430
|
| Accessions |
AAD13155 AAK68906 EAW52707 EAW52708 EAW52709 EAW52710 EAW52711 EAW52712 Q9UIB8 AF054815 AAF21721 AF054816 AAF21722 AF054817 AAF21723 AF054818 AAF21724 AJ223324 CAA11264 AK296290 BAH12304 AK313496 BAG36278 BC020063 AAH20063 CA448708 CR541847 CAG46645 CR933666 CAI45963 DQ891708 ABM82634 DQ894872 ABM85798 U82988 AAB84364 U96627 AAD04232 Y12632 CAA73181 XM_011510094 XP_011508396 XM_011510095 XP_011508397 XR_921991 NM_001184879 NP_001171808 NM_001184881 NP_001171810 NM_001184882 NP_001171811 NM_003874 NP_003865
|
| Function |
Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain- containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells. {ECO:0000269|PubMed:11564780, ECO:0000269|PubMed:12115647, ECO:0000269|PubMed:12928397, ECO:0000269|PubMed:12962726, ECO:0000269|PubMed:16037392}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:11389028, ECO:0000269|PubMed:12962726}; Single-pass type I membrane protein {ECO:0000269|PubMed:11389028, ECO:0000269|PubMed:12962726}.
|
| Tissue Specificity |
Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells. {ECO:0000269|PubMed:10698700, ECO:0000269|PubMed:11564780, ECO:0000269|PubMed:12115647, ECO:0000269|PubMed:12962726, ECO:0000269|PubMed:15245368, ECO:0000269|PubMed:9310491}.
|