| Gene Symbol | MMP1 |
|---|---|
| Entrez Gene | 4312 |
| Alt Symbol | CLG, CLGN |
| Species | Human |
| Gene Type | protein-coding |
| Description | matrix metallopeptidase 1 |
| Other Description | fibroblast collagenase|interstitial collagenase|matrix metallopeptidase 1 (interstitial collagenase)|matrix metalloprotease 1|matrix metalloproteinase 1 |
| Swissprots | P08156 P03956 |
| Accessions | AAA52033 AAB36941 AAV28732 CCQ43177 EAW67031 P03956 AK024818 AK098450 AK130687 AK223034 BAD96754 AK223035 BAD96755 AK223036 BAD96756 AK223056 BAD96776 AK223281 BAD97001 AK225495 AK297723 BAG60077 AK301340 BAG62888 BC013118 AAH13118 BC013875 AAH13875 BT006874 AAP35520 BT020147 AAV38949 DC385245 DQ399597 ABD92796 DQ890729 ABM81655 DQ893904 ABM84830 M13509 AAA35699 M15996 AAA35700 X05231 CAA28858 X54925 CAA38691 NM_001145938 NP_001139410 NM_002421 NP_002412 |
| Function | Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity. {ECO:0000269|PubMed:1645757}. |
| Subcellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:2167156}. |
| Top Pathways | Bladder cancer, PPAR signaling pathway, Rheumatoid arthritis |